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Table 4 Potential causes of thyrotropin elevation in patients (thyroxine treated) with primary hypothyroidism

From: The biopsychosocial model and hypothyroidism

Suboptimal dosing, inadequate prescribed dosage, dispensing error
Non compliance
Progressive decrease in endogenous thyroxine production
Drug and supplement interactions
Malabsorption disorders
Autoimmune thyroiditis
Previous thyroid irradiation
Reduced thyroxine absorption
Other systemic illnesses