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Table 4 Potential causes of thyrotropin elevation in patients (thyroxine treated) with primary hypothyroidism

From: The biopsychosocial model and hypothyroidism

Suboptimal dosing, inadequate prescribed dosage, dispensing error
Non compliance
Progressive decrease in endogenous thyroxine production
Drug and supplement interactions
Co-morbidities
Malabsorption disorders
Autoimmune thyroiditis
Previous thyroid irradiation
Reduced thyroxine absorption
Other systemic illnesses