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Table 2 Summary of the overall quality of the body of evidence

From: Is manipulative therapy more effective than sham manipulation in adults?: a systematic review and meta-analysis

Type of outcome measure (population)

Time frame

(Number of studies) Number of participants

Summary of the quality of the evidence

Reasons for downgrading

Pain (variety of complaints)

On all time points

(7RCTs) 389

Low evidence:

Risk of bias/imprecision

MT provides better pain relief than sham

 

Immediate

(3RCTs) 117

Moderate evidence:

Incons

MT provides better pain relief than sham

 

Short-term

(4RCTs) 272

Low evidence:

Risk of bias/imprecision

MT provides better pain relief than sham

 

Long- term

(1RCT) 62

Low evidence:

Incons./imprecision

MT provides better pain relief than sham

Pain (musculoskeletal disorders)

On all time points

(5RCTs) 208

Low evidence:

Risk of bias/imprecision

MT provides better pain relief than sham

 

Immediate

(2RCTs) 73

Moderate evidence:

imprecision

MT provides better pain relief than sham

 

Short-term

(3RCTs) 135

Low evidence:

Risk of bias/imprecision

MT provides better pain relief than sham

 

Long- term

(1RCT) 62

Low evidence:

Incons./imprecision

MT provides better pain relief than

Pain (neck pain)

Immediate

(2RCTs) 73

Low evidence:

Incons./imprecision

MT does not provide better pain relief than sham

Pain (low back pain)

Short-term

(2RCTs) 126

Low evidence:

Risk of bias/imprecision

MT provides better pain relief than sham

Pain (primary dysmenorrhea)

On all time points

(2RCTs) 181

Low evidence:

incons./imprecision

MT does not provide better pain relief than sham

Pain (chiropractor)

On all time points

(3RCTs) 190

Very low evidence:

Risk of bias/incons./imprecision

MT does not provide better pain relief than sham

Pain (physical therapist)

On all time points

(3RCTs) 137

Low evidence:

Risk of bias/imprecision

MT performed by physical therapist provides better pain relief than sham

Pain (physician)

On all time points

(1RCT) 62

Low evidence:

incons./imprecision

MT performed by a physician therapist provides better pain relief than sham

Disability (muscoloskeletal disorders)

Short term

(6RCTs) 355

Very low evidence:

Risk of bias/incons./imprecision

MT does not provide better relief of disability than sham

Perceived (asthma) recovery (chronic asthma)

Short term

(1RCTs) 31

Very low evidence:

Risk of bias/incons./imprecision

MT does not provide better perceived (asthma) recovery than sham

  1. incons. = inconsistency.