Table 3 Results of the first stage of two-stage clustering of chest pain data
Response option | |||||||
|---|---|---|---|---|---|---|---|
Domain: Demographic | |||||||
2 clusters | Cluster1 | Cluster2 | |||||
Scoring pattern label | Older | Younger | |||||
Cluster Size | 51 % | 49 % | |||||
Cluster membership probability | Median (interquartile range) | 90 % (79 % to 96 %) | 93 % (78 % to 100 %) | ||||
Age (years) | Mean (SD) | 62.6 (5.2) | 45.3 (6.3) | ||||
Gender | Female | 43 % | 39 % | ||||
Domain: Previous history | |||||||
1 cluster | Previous history did not discriminate subgroups in two-stage clustering | ||||||
Domain: Psychological | |||||||
5 clusters | Cluster1 | Cluster2 | Cluster3 | Cluster4 | Cluster5 | ||
Scoring pattern label | Uncertain of cause of pain and fearful | Believes cause from heart | Believes both from heart and musculoskeletal | Believes cause from musculoskeletal and less fearful | Believes cause from other cause and less fearful | ||
Cluster Size | 44 % | 23 % | 16 % | 11 % | 6 % | ||
Cluster membership probability | Median (interquartile range) | 100 % (92 % to 100 %) | 99. % (99 % to 100 %) | 100 % (100 % to 100 %) | 95 % (95 % to 96 %) | 77 % (77 % to 100 %) | |
Self-perceived ‘Pain from muscle or joints’ | No | 10 % | 100 % | 0 % | 0 % | 75 % | |
Possibly | 85 % | 0 % | 1 % | 13 % | 25 % | ||
Yes | 5 % | 0 % | 99 % | 87 % | 0 % | ||
Self-perceived ‘Pain from heart’ | No | 15 % | 0 % | 0 % | 99 % | 94 % | |
Possibly | 83 % | 1 % | 1 % | 1 % | 6 % | ||
Yes | 3 % | 99 % | 99 % | 0 % | 0 % | ||
Self-perceived ‘Afraid’ | Yes | 99 % | 71 % | 83 % | 56 % | 50 % | |
Domain: Pain | |||||||
2 clusters | Cluster1 | Cluster2 | |||||
Scoring pattern label | Crushing pain | Not crushing pain | |||||
Cluster Size | 77 % | 23 % | |||||
Cluster membership probability, median (interquartile range) | 97 % (94 % to 97 %) | 99 % (96 % to 99 %) | |||||
Episode duration | < 10 min | 59 % | 50 % | ||||
10 min-1 hour | 20 % | 20 % | |||||
> 1 hour | 5 % | 7 % | |||||
Continuous | 16 % | 24 % | |||||
Pain description ‘crushing pain’ | Yes | 100 % | 25 % | ||||
Pain description ‘tenderness’ | Yes | 3 % | 3 % | ||||
Pain description ‘sharp pains’ | Yes | 14 % | 52 % | ||||
Pain description ‘well defined’ | Yes | 3 % | 6 % | ||||
Pain description ‘diffuse’ | Yes | 6 % | 5 % | ||||
Pain description ‘burning’ | Yes | 4 % | 8 % | ||||
Pain description ‘tingling’ | Yes | 8 % | 19 % | ||||
Domain: Activity limitation | |||||||
3 clusters | Cluster1 | Cluster2 | Cluster3 | ||||
Scoring pattern label | None or light activity limitation | Moderate activity limitation | Severe activity limitation | ||||
Cluster Size | 82 % | 11 % | 8 % | ||||
Cluster membership probability, median (interquartile range) | 100 % (100 % to 100 %) | 86 % (86 % to 86 %) | 99 % (82 % to 100 %) | ||||
SF36 physical function sum-score | Mean (SD) | 71.2 (7.4) | 49.0 (4.6) | 27.1 (6.9) | |||
Domain: Diagnostic classification | |||||||
3 clusters | Cluster1 | Cluster2 | Cluster3 | ||||
Scoring pattern label | Not heart | Typical angina | Maybe angina | ||||
Cluster Size | 37 % | 35 % | 28 % | ||||
Cluster membership probability | Median (interquartile range) | 100 % (94 % to 100 %) | 100 % (85 % to 100 %) | 97 % (81 % to 100 %) | |||
Danish Cardiologist’s Society | No angina | 64 % | 3 % | 2 % | |||
classification ‘angina’ | Typical | 0 % | 89 % | 4 % | |||
Atypical | 1 % | 8 % | 65 % | ||||
Uncharacteri-stic | 34 % | 0 % | 29 % | ||||
Unstable | 0 % | 1 % | 0 % | ||||
Canadian Cardiovascular Society | Grade 0 | 87 % | 0 % | 8 % | |||
classification | Grade 1 | 13 % | 17 % | 84 % | |||
Grade 2 | 0 % | 76 % | 8 % | ||||
Grade 3 | 0 % | 7 % | 0 % | ||||
Domain: Palpation | |||||||
6 clusters | Cluster1 | Cluster2 | Cluster3 | Cluster4 | Cluster5 | Cluster6 | |
Scoring pattern label | No palpation findings | Local 5/6 signs and intercostal tenderness | Local 2/3/4 signs and pectoral tenderness | Pectoral tenderness | Paraspinal and pectoral tenderness | Generalised tenderness | |
Cluster Size | 22 % | 19 % | 18 % | 16 % | 16 % | 8 % | |
Cluster membership probability, median (interquartile range) | 100 % (100 % to 100 %) | 100 % (100 % to 100 %) | 100 % (100 % to 100 %) | 100 % (100 % to 100 %) | 100 % (100 % to 100 %) | 100 % (100 % to 100 %) | |
Sternoxiphoid springing tenderness | Yes | 10 % | 22 % | 1 % | 1 % | 10 % | 34 % |
Costosternal tenderness 2/3 right | Yes | 0 % | 5 % | 1 % | 4 % | 16 % | 52 % |
Costosternal tenderness 2/3 left | Yes | 1 % | 7 % | 0 % | 2 % | 19 % | 56 % |
Costosternal tenderness 3/4 right | Yes | 2 % | 13 % | 1 % | 3 % | 12 % | 52 % |
Costosternal tenderness 3/4 left | Yes | 2 % | 25 % | 0 % | 0 % | 18 % | 54 % |
Costosternal tenderness 4/5 right | Yes | 1 % | 28 % | 1 % | 1 % | 4 % | 51 % |
Costosternal tenderness 4/5 left | Yes | 2 % | 77 % | 1 % | 1 % | 10 % | 52 % |
Costosternal tenderness 5/6 right | Yes | 1 % | 27 % | 1 % | 1 % | 0 % | 51 % |
Costosternal tenderness 5/6 left | Yes | 3 % | 55 % | 0 % | 0 % | 6 % | 51 % |
sternoxiphoid springing pain | Yes | 4 % | 3 % | 0 % | 0 % | 4 % | 4 % |
Costosternal springing pain 2/3 right | Yes | 0 % | 0 % | 0 % | 4 % | 1 % | 8 % |
Costosternal springing pain 2/3 left | Yes | 0 % | 1 % | 0 % | 1 % | 4 % | 10 % |
Costosternal springing pain 3/4 right | Yes | 0 % | 2 % | 1 % | 2 % | 2 % | 10 % |
Costosternal springing pain 3/4 left | Yes | 1 % | 7 % | 0 % | 0 % | 5 % | 10 % |
Costosternal springing pain 4/5 right | Yes | 0 % | 8 % | 1 % | 0 % | 1 % | 6 % |
Costosternal springing pain 4/5 left | Yes | 1 % | 36 % | 0 % | 0 % | 0 % | 4 % |
Costosternal springing pain 5/6 right | Yes | 0 % | 9 % | 0 % | 0 % | 0 % | 4 % |
Costosternal springing pain 5/6 left | Yes | 0 % | 29 % | 0 % | 1 % | 2 % | 6 % |
Muscle tenderness pectoralis major left | Tenderness | 1 % | 19 % | 78 % | 62 % | 38 % | 54 % |
Pain | 0 % | 3 % | 20 % | 28 % | 4 % | 24 % | |
Muscle tenderness pectoralis minor left | Tenderness | 2 % | 31 % | 83 % | 75 % | 40 % | 66 % |
Pain | 0 % | 6 % | 13 % | 8 % | 4 % | 20 % | |
Muscle tenderness intercostal 2/3 left | Tenderness | 1 % | 6 % | 58 % | 42 % | 24 % | 84 % |
Pain | 1 % | 0 % | 3 % | 1 % | 0 % | 12 % | |
Muscle tenderness intercostal 3/4 left | Tenderness | 1 % | 20 % | 36 % | 20 % | 18 % | 90 % |
Pain | 1 % | 2 % | 0 % | 0 % | 1 % | 8 % | |
Muscle tenderness intercostal 4/5 left | Tenderness | 3 % | 46 % | 12 % | 10 % | 5 % | 91 % |
Pain | 1 % | 15 % | 0 % | 1 % | 1 % | 6 % | |
Muscle tenderness intercostal 5/6 left | Tenderness | 2 % | 57 % | 5 % | 3 % | 4 % | 89 % |
Pain | 0 % | 21 % | 0 % | 0 % | 0 % | 6 % | |
Muscle tenderness intercostal 6/7 left | Tenderness | 1 % | 42 % | 1 % | 1 % | 0 % | 82 % |
Pain | 0 % | 14 % | 0 % | 1 % | 1 % | 8 % | |
Muscle tenderness pectoralis major right | Tenderness | 0 % | 16 % | 75 % | 74 % | 28 % | 56 % |
Pain | 0 % | 0 % | 21 % | 16 % | 4 % | 24 % | |
Muscle tenderness pectoralis minor right | Tenderness | 1 % | 17 % | 80 % | 68 % | 33 % | 66 % |
Pain | 0 % | 0 % | 11 % | 7 % | 1 % | 20 % | |
Muscle tenderness intercostal 2/3 right | Tenderness | 0 % | 9 % | 59 % | 38 % | 16 % | 90 % |
Pain | 0 % | 1 % | 0 % | 1 % | 1 % | 8 % | |
Muscle tenderness intercostal 3/4 right | Tenderness | 1 % | 15 % | 32 % | 15 % | 9 % | 90 % |
Pain | 0 % | 0 % | 0 % | 1 % | 1 % | 6 % | |
Muscle tenderness intercostal 4/5 right | Tenderness | 0 % | 27 % | 10 % | 4 % | 4 % | 90 % |
Pain | 0 % | 2 % | 0 % | 0 % | 0 % | 4 % | |
Muscle tenderness intercostal 5/6 right | Tenderness | 0 % | 30 % | 3 % | 1 % | 0 % | 89 % |
Pain | 0 % | 4 % | 0 % | 0 % | 0 % | 4 % | |
Muscle tenderness intercostal 6/7 right | Tenderness | 0 % | 17 % | 2 % | 2 % | 0 % | 84 % |
Pain | 0 % | 5 % | 0 % | 0 % | 0 % | 4 % | |
Tenderness c4/5 paraspinal posterior | Yes | 3 % | 6 % | 6 % | 1 % | 17 % | 27 % |
Tenderness c5/6 paraspinal posterior | Yes | 4 % | 13 % | 11 % | 3 % | 20 % | 26 % |
Tenderness c6/7 paraspinal posterior | Yes | 3 % | 13 % | 8 % | 3 % | 12 % | 19 % |
Tenderness c7/th1 paraspinal posterior | Yes | 1 % | 8 % | 18 % | 0 % | 9 % | 21 % |
Tenderness th1/2 paraspinal posterior | Yes | 2 % | 14 % | 50 % | 0 % | 20 % | 31 % |
Tenderness th2/3 paraspinal posterior | Yes | 3 % | 27 % | 89 % | 0 % | 46 % | 51 % |
Tenderness th3/4 paraspinal posterior | Yes | 1 % | 33 % | 78 % | 0 % | 54 % | 61 % |
Tenderness th4/5 paraspinal posterior | Yes | 1 % | 38 % | 40 % | 1 % | 59 % | 59 % |
Tenderness th5/6 paraspinal posterior | Yes | 1 % | 45 % | 13 % | 0 % | 53 % | 41 % |
Tenderness th6/7 paraspinal posterior | Yes | 1 % | 43 % | 1 % | 0 % | 45 % | 35 % |
Tenderness th7/8 paraspinal posterior | Yes | 3 % | 27 % | 2 % | 0 % | 26 % | 33 % |
Tenderness th8/9 paraspinal posterior | Yes | 2 % | 12 % | 0 % | 0 % | 17 % | 25 % |
Posterior vertebral springing th1/2 | Yes | 0 % | 8 % | 10 % | 2 % | 4 % | 2 % |
Posterior vertebral springing th2/3 | Yes | 1 % | 7 % | 41 % | 11 % | 18 % | 17 % |
Posterior vertebral springing th3/4 | Yes | 0 % | 21 % | 51 % | 11 % | 21 % | 26 % |
Posterior vertebral springing th4/5 | Yes | 0 % | 15 % | 31 % | 5 % | 18 % | 28 % |
Posterior vertebral springing th5/6 | Yes | 0 % | 14 % | 12 % | 0 % | 24 % | 17 % |
Posterior vertebral springing th6/7 | Yes | 1 % | 19 % | 2 % | 0 % | 19 % | 11 % |
Posterior vertebral springing th7/8 | Yes | 2 % | 12 % | 1 % | 2 % | 14 % | 11 % |
Posterior vertebral springing th8/9 | Yes | 5 % | 9 % | 1 % | 0 % | 10 % | 19 % |