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Table 4 Results of the second stage of two-stage clustering (described using the prevalence of first stage cluster membership)

From: Could the clinical interpretability of subgroups detected using clustering methods be improved by using a novel two-stage approach?

Domain

 

Cluster 1

Cluster 2

Subgroup label

 

Uncertain of cause and fearful, but not heart-related - with local thoracic 5/6 palpation findings.

Believes pain to be heart- or musculoskelet-al-related with crushing pain, and local thoracic 2/3 signs and pectoral tenderness.

Cluster size

 

51 %

49 %

Cluster membership probability

Median (interquartile range)

100 % (99 % to 100 %)

100 % (98 % to 100 %)

Demographic

Younger

42 %*

62 %

 

Older

58 %

38 %

Previous history

 

0 %

0 %

 

Only one cluster

100 %

100 %

Psychological

Uncertain of cause of pain and fearful

88 %

2 %

 

Believes cause from heart

1 %

44 %

 

Believes both from heart and musculoskeletal

0 %

31 %

 

Believes cause from musculoskeletal and less fearful

6 %

14 %

 

Believes cause from other cause and less fearful

5 %

8 %

Pain

Crushing pain

74 %

89 %

 

Not crushing pain

26 %

11 %

Activity limitation

None or light activity limitation

88 %

76 %

 

Moderate activity limitation

8 %

13 %

 

Severe activity limitation

4 %

11 %

Diagnostic

classification

Not heart

71 %

1 %

 

Typical angina

13 %

61 %

 

Maybe angina

16 %

38 %

Palpation

No palpation findings

23 %

23 %

 

Local 5/6 signs and intercostal tenderness

36 %

1 %

 

Local 2/3/4 signs and pectoral tenderness

4 %

32 %

 

Pectoral tenderness

3 %

30 %

 

Paraspinal and pectoral tenderness

23 %

8 %

 

Generalised tenderness

11 %

6 %

  1. *Proportions are those of the people within each cluster on each domain (vertical proportions), as each category within a domain is mutually exclusive