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Table 3 Mean baseline clinical characteristics

From: A biopsychosocial approach to primary hypothyroidism: treatment and harms data from a randomized controlled trial

Outcome measure

 

Treatment

Placebo

 

Normal range

Median (Min, Max)

Mean (SD)

Median (Min, Max)

Mean (SD)

Thyroid function tests:

     

 TSH (mIU/L)

0.40–3.50

0.96 (0.00, 55.77)

2.98 (8.39)a

1.34 (0.01, 7.30)

1.85 (1.76)

 FT4 (pmol/L)

9.0–19.0

15.00 (7.00, 26.00)

15.09 (3.22)

14.20 (3.80, 24.50)

14.51 (3.91

 FT3 (pmol/L)

2.6–6.0

4.06 (2.80, 7.45)

4.13 (0.80)

3.80 (3.00, 5.73)

3.95 (0.64)

DASS Scores:

     

 Depression

0–9

6.50 (0.00, 29.00)

9.43 (8.60)

6.00 (0.00, 41.00)

7.85 (8.52)

 Anxiety

0–7

6.00 (0.00, 19.00)

6.79 (5.13)

4.00 (0.00, 30.00)

6.27 (7.73)

 Stress

0–14

13.00 (3.00, 35.00)

13.71 (8.28)

11.00 (2.00, 38.00)

12.76 (8.53)

SF-36v2 Scores:

Normal Mean (SD)

Median (Min, Max)

Mean (SD)

Median (Min, Max)

Mean (SD)

 Physical functioning

50 ± 3 (10)

52.82 (25.46, 57.03)

48.06 (8.36)

50.72 (29.68, 57.03)

48.66 (7.72)

 Role physical

50 ± 3 (10)

49.51 (22.57, 56.85)

48.85 (8.60)

51.96 (17.67, 56.85)

46.32 (11.25)

 Bodily pain

50 ± 3 (10)

46.06 (24.08, 62.12)

49.97 (9.87)

46.06 (24.08, 62.12)

46.53 (9.43)

 General health

50 ± 3 (10)

45.31 (23.38, 57.70)

43.72 (11.26)

45.78 (23.78, 62.47)

45.16 (9.71)

 Vitality

50 ± 3 (10)

39.60 (23.99, 58.33)

40.15 (8.88)

41.16 (20.87, 58.33)

41.68 (10.33)

 Social functioning

50 ± 3 (10)

45.94 (13.22, 56.86)

42.09 (12.49)

45.94 (13.22, 56.85)

41.12 (12.82)

 Role emotional

50 ± 3 (10)

48.10 (20.89, 55.88)

44.78 (10.71)

44.22 (20.89, 55.88)

43.58 (10.96)

 Mental health

50 ± 3 (10)

44.38 (21.85, 61.27)

43.79 (11.04)

47.19 (16.22, 58.46)

43.03 (11.62)

 Physical component summary

50 ± 3 (10)

50.46 (30.08, 61.73)

48.27 (7.76)

51.39 (16.70, 59.78)

48.45 (9.54)

 Mental component summary

50 ± 3 (10)

42.59 (16.70, 60.18)

41.10 (11.49)

41.59 (16.40, 61.35)

40.79 (12.71)

 

Normal Range

Median (Min, Max)

Mean (SD)

Median (Min, Max)

Mean (SD)

 Resting temperature (°C)

35.5–37.03

35.8 (32.8, 37.0)

35.6 (0.9)

35.6 (33.4, 36.6)

35.6 (0.7)

 Resting heart rate (bpm)

75–85

64 (30, 86)

65.7 (9.6)

64 (44, 86)

63.9 (11.3)

  1. The SF-36v2 scores are based on the norm based scoring system (NBS) which is based on a mean score with a normal range between 47 and 53 NBS points. Resting temperature and resting heart rate data were analysed based on ‘Day 1’ dairy entries
  2. aStrongly influenced by one person with very high TSH
  3. DASS Depression, Anxiety, Stress Score, NET Neuro-Emotional Technique, TSH Serum thyroid stimulating hormone, FT4 Free thyroxine, FT3 Free triiodothyronine, SF-36v2 Short Form-36 Version 2, Min minimum, Max Maximum, SD standard deviation