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Table 2 Mean scores, regression coefficients, and odds ratios for primary and secondary outcomes, and responder analyses (Intention to Treat, N = 181)

From: Manual therapy compared with physical therapy in patients with non-specific neck pain: a randomized controlled trial

Variables Manual therapy Utrecht (n = 90) Physiotherapy (n = 91) Regression coefficients (95% CI)
Primary outcomes measures
GPE (success, %)    OR (95% CI) P
 Overall effect: P = 0.20
  3 weeks. 30.7 14.8 3.97 (1.31 to 12.04) 0.02**
  7 weeks. 51.7 42.4 1.90 0.69 to 5.20) 0.21
  13 weeks. 60.7 57.0 1.11 (0.39 to 3.15) 0.84
  26 weeks. 57.5 59.5 0.76 (0.26 to 2.18) 0.61
  52 weeks. 64.9 56.0 1.72 (0.61to 4.88) 0.31
NDI (0–50) (M, SD)    Regression Coefficients (95% CI) P
 Overall effect: P =0.57
  Baseline 12.5 (6.8) 11.7 (5.4)   
  3 weeks. 10.5 (6.9) 10.2 (5.6) −0.24 (−1.65 to 1.16) 0.74
  7 weeks. 7.8 (6.4) 8.1 (7.1) −0.69 (−2.14 to 0.76) 0.35
  13 weeks. 5.9 (5.8) 5.9 (4.6) −0.23 (−1.67 to 1.21) 0.75
  26 weeks. 5.9 (5.5) 5.6 (5.6) 0.34 (−1.11 to 1.80) 0.64
  52 weeks. 5.9 (5.7) 6.6 (6.5) −0.82 (−2.25 to 0.61) 0.26
Secondary outcomes measures
NRS-P (0–10) (M, SD)
 Overall effect: P = 0.76
  Baseline 5.5 (2.0) 5.8 (1.8)   
  3 weeks. 4.2 (2.3) 4.6 (2.1) −0.27 (−0.94 to 0.40) 0.42
  7 weeks. 3.2 (2.3) 3.6 (2.4) −0.20 (−0.87 to 0.47) 0.56
  13 weeks. 2.8 (2.5) 2.6 (2.0) 0.24 (−0.44 to 0.93) 0.49
  26 weeks. 2.9 (2.4) 2.3 (2.2) 0.78 (0.09 to 1.47) 0.03**
  52 weeks. 2.5 (2.6) 2.8 (2.6) −1.14 (−0.82 to 0.54) 0.69
Responder analyses
MCID NDI (success, %)   OR (95% CI) P
 Overall effect: P = 0.95
  3 weeks. 31.0 20.7 2.08 (0.79 to 5.43) 0.14
  7 weeks. 56.3 52.0 1.26 (0.49 to 3.24) 0.63
  13 weeks. 66.3 65.8 0.97 (0.37 to 2.53) 0.95
  26 weeks. 62.0 69.6 0.55 (0.21 to 1.47) 0.23
  52 weeks. 60.5 63.1 0,79 (0.31 to 2.02) 0.63
MCID NRS-P (success, %)
 Overall effect: P = 0.11
  3 weeks. 34.9 37.2 0.87 (0.38 to 2.14) 0.73
  7 weeks. 55.2 56.6 0.95 (0.42 to 2.14) 0.89
  13 weeks. 59.4 65.2 0.56 (0.23 to 1.38) 0.21
  26 weeks. 58.2 79.5 0.25 (0.10 to 0.63) 0.00**
  52 weeks. 69.1 69.9 0.93 (0.39 to 2.25) 0.88
  1. Values presented are model estimates of general linear mixed-effects models with a random intercept and adjusted for baseline and location. Regression coefficients can be interpreted as mean differences between interventions at a certain follow-up moment compared with baseline. Positive values favor the manual therapy group For Odds Ratios the reference group is physiotherapy
  2. Abbreviations: ITT intention-to-treat, CI confidence interval, GPE global perceived effect, NDI Neck Disability Index, NRS-P Numerical Rating Scale for Pain, OR odds ratio, MCID Minimal Clinical Important Difference