Cost-effectiveness of spinal manipulation, exercise, and self-management for spinal pain using an individual participant data meta-analysis approach: a study protocol

Table 1 Clinical trial populations and interventions

	Population			Interventions
	Condition	Sample	Age	Group 1	Group 2	Group 3
Pre-dates CT.gov [29]	Chronic neck pain	191	20–65	SMT + ET	ET	SMT
NCT00269360 [22]	Chronic neck pain	270	18–65	SMT + ET	ET	SC
NCT00269308 [23]	Chronic neck pain	241	65+	SMT + SC	ET + SC	SC
NCT00029770 [28]	Acute neck pain	272	18–65	SMT	SC	Medication
NCT00269347 [24]	Chronic low back pain	301	18–65	SMT	ET	SC
NCT00269321 [25]	Chronic low back pain	240	65+	SMT + SC	ET + SC	SC
NCT00494065 [26]	Chronic back-related leg pain	192	21+	SMT + SC	SC	–
NCT01096628 [27]	Chronic low back pain	184	12–18	SMT + ET	ET	–

CNP chronic neck pain, ANP acute neck pain, CLBP chronic low back pain, BRLP back related leg pain, SMT spinal manipulation therapy, ET exercise therapy, SC self-care