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Table 3 The AGREE II Instrument

From: Systematic review of guideline-recommended medications prescribed for treatment of low back pain

AGREE II domains and items


Domain 1. Scope and Purpose


1. The overall objective(s) of the guideline is (are) specifically described


2. The health question(s) covered by the guideline is (are) specifically described


3. The population (patients, public, etc.) to whom the guideline is meant to apply is specifically described


Domain 2. Stakeholder Involvement


4. The guideline development group includes individuals from all relevant professional groups


5. The views and preferences of the target population (patients, public, etc.) have been sought


6. The target users of the guideline are clearly defined


Domain 3. Rigor of Development


7. Systematic methods were used to search for evidence


8. The criteria for selecting the evidence are clearly described


9. The strengths and limitations of the body of evidence are clearly described


10. The methods for formulating the recommendations are clearly described


11. The health benefits, side effects, and risks have been considered in formulating the recommendations


12. There is an explicit link between the recommendations and the supporting evidence


13. The guideline has been externally reviewed by experts prior to its publication


14. A procedure for updating the guideline is provided


Domain 4. Clarity of Presentation


15. The recommendations are specific and unambiguous


16. The different options for management of the condition or health issue are clearly presented


17. Key recommendations are easily identifiable


Domain 5. Applicability


18. The guideline describes facilitators and barriers to its application


19. The guideline provides advice and/or tools on how the recommendations can be put into practice


20. The potential resource implications of applying the recommendations have been considered


21. The guideline presents monitoring and/or auditing criteria


Domain 6. Ethical Independence


22. The views of the funding body have not influenced the content of the guideline


23. Competing interests of guideline development group members have been recorded and addressed

  1. AGREE II, Appraisals of Guidelines for Research and Evaluation, Version II