Table 1 Aetiology of Hypothyroidism
Category | Cause |
|---|---|
Autoimmune | Hashimoto's Thyroiditis, Reidels Disease, previous Graves disease, de Quervains thyroiditis, postpartum thyroiditis, Downs syndrome, family history of autoimmune disease or associated disorders (vitiligo, adrenal insufficiency, diabetes mellitus type-1, Sjogren's, coeliac disease), Turner's syndrome, Multiple Sclerosis, primary pulmonary hypertension |
Nutritional | Iodine deficiency, excess intake of goitrogens, excessive iodine intake |
Environmental | Radiation Exposure, exposure to polybrominated and polychlorinated biphenyls and resorcinol |
Iatrogenic | Radioactive iodine therapy, medical radiation exposure, total or subtotal thyroidectomy, drugs impairing thyroid function (amiodarone, thalidomide, betaroxine, lithium carbonate, stavudine, aminoglutethimide) |
Hypothalamic | Hypothalamic or suprasellar mass, history of hypothalamic radiotherapy or surgery, disorders causing hypothalamic dysfunction (eg sarcoidosis, heamochromatosis) |
Pituitary | Known pituitary tumour, other elements of hypopituitarism, manifestations of sellar mass, history of pituitary surgery or radiotherapy, history of head trauma |
Other | Postpartum status |