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Autoimmune
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Hashimoto's Thyroiditis, Reidels Disease, previous Graves disease, de Quervains thyroiditis, postpartum thyroiditis, Downs syndrome, family history of autoimmune disease or associated disorders (vitiligo, adrenal insufficiency, diabetes mellitus type-1, Sjogren's, coeliac disease), Turner's syndrome, Multiple Sclerosis, primary pulmonary hypertension
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Nutritional
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Iodine deficiency, excess intake of goitrogens, excessive iodine intake
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Environmental
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Radiation Exposure, exposure to polybrominated and polychlorinated biphenyls and resorcinol
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Iatrogenic
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Radioactive iodine therapy, medical radiation exposure, total or subtotal thyroidectomy, drugs impairing thyroid function (amiodarone, thalidomide, betaroxine, lithium carbonate, stavudine, aminoglutethimide)
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Hypothalamic
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Hypothalamic or suprasellar mass, history of hypothalamic radiotherapy or surgery, disorders causing hypothalamic dysfunction (eg sarcoidosis, heamochromatosis)
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Pituitary
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Known pituitary tumour, other elements of hypopituitarism, manifestations of sellar mass, history of pituitary surgery or radiotherapy, history of head trauma
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Other
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Postpartum status
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