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Table 1 Description of the 16 candidate variables

From: Potential effect modifiers for treatment with chiropractic manipulation versus sham manipulation for recurrent headaches in children aged 7–14 years: development of and results from a secondary analysis of a randomised clinical trial

Candidate variable

Formation from baseline questionnaire

 

Headache characteristics

Intensity of headache

Numerical rating scale (NRS) from 0 to 10

 

Frequency of headache

Number of days with headache per week. 1–2 days/3–5 day/nearly every day

 

Duration of headache

0.5–1 year/1–3 years/more than 3 years

 

Length of episodes

 < 2 h/half day/whole day/day and night

 

Absence from school

0/1–5/5–20/ > 20 days last year

 

Co-occurring symptoms

Summary index based on four binary items: nausea, vomiting, light sensitivity, and sound sensitivity

 

Migraine-tension-type

Continuous index based on severity and co-occurring symptoms (high values indicating migraine, low values tension type headache). Derived from previous analyses of the same cohort [17]

 

Variables identified from the literature

Relationship with headache

Age

Reported age in years

Headache prevalence rises with age and there is a significant increase in headache prevalence after age 12 [18, 19]

Sport activity

"0 times”,”1–3 times", or " > 3 times"

Low physical activity is associated with recurrent headaches in adolescents [20,21,22]

Screen time

“low”, “normal”, or “high” based on age-specific cut points for the self-reported screen time

A forward head posture, as often assumed in front of computers, has been associated with neck and shoulder pain [5, 23]

Sleep duration

“low”, “normal”, or “high” based on age-specific cut points for the self-reported sleep duration

Poor quality of sleep is associated with headache in children [24,25,26] and this association is particularly evident in migraine [24]. Children with headache report more daytime symptoms of sleep disturbances, including fatigue, tiredness, and sleepiness [27]. Furthermore, excessive screen time may influence headache mediated by less sleep, and reduced sleep duration can be an indicator of an unhealthy lifestyle [28]

Trauma experience

Summary index based on three items on lifetime trauma experience (no need for treatment, need for treatment, hospitalization)

The cervical spine is the most commonly injured region of the spine in young children [29, 30] and thus cervicogenic headache might be a consequence of cervical dysfunction

History of concussion

Binary item on lifetime experience of concussions

In adults, headache associated with head injury is estimated to persist for 12 to 24 months after the injury in 20–30% [31]

History of neck pain

Report of neck pain within the past year

The cervical spine is the most commonly injured region of the spine in young children [29, 30] and thus cervicogenic headache might be a consequence of cervical dysfunction

Socioeconomic status

Income is here considered as a proxy for socioeconomic status: self-reported annual income in 8 categories (labelled in 1000 €)

Socioeconomically disadvantaged children are more prone to headache [32]

Headache in the family

Presence of headache in the parents: “none”, “one parent “, or “both parents”

A history of headache in a first-degree family member has been reported in up to 72% of children with headache with a predominance of maternal headache[19, 25, 33, 34]