- Systematic review
- Open Access
Effects of manual therapies on stability in people with musculoskeletal pain: a systematic review
Chiropractic & Manual Therapies volume 28, Article number: 13 (2020)
Chronic musculoskeletal pain is associated with reduced balance performance and falls risk. Manual therapies are commonly used interventions for musculoskeletal pain. There is emerging evidence that manual therapies may improve balance. The aim of this systematic review was to examine the effectiveness of manual therapies for musculoskeletal pain on measures of static and dynamic stability.
Six electronic databases were searched using pre-defined eligibility criteria and two independent reviewers assessed all identified records. Risk of bias was assessed using the 12-item Cochrane Risk of Bias assessment by two authors independently and any discrepancies resolved through consensus. Meta-analysis was conducted when three or more studies used the same outcome measures including gait speed, timed up and go test, step test and sit-to-stand test.
Twenty-six studies were included in the analysis. Both spinal and extremity musculoskeletal pain conditions were represented. Manual therapies included manipulation, mobilisation and massage. The most common intervention compared to manual therapy was exercise. Outcome measures included both clinical and objective measures of stability. Overall the risk of bias was reported as generally low or unclear.
Improvement in stability measures were reported in studies comparing manual therapy in the short term, but not long-term follow-up. There was no clear association between significant pain reduction and measures of stability. Further prospective studies are recommended to investigate whether manual therapies should be part of an integrative healthcare plan for risk of falls management and when a transition from manual therapy to more active interventions should occur for long term management.
The global population is ageing, as exemplified by recent Eurostat population data which estimates that the population of people aged 65 years and older will increase from 18% in 2013 to 28% in 2060 . Ageing increases the risk of escalating morbidity (people living longer in poor health) .
Fall related injury in older people is a major health problem [3, 4]. Stiffer, less coordinated gait, poor balance control and decreased muscle strength have been cited as major causes of falls in older people [4, 5]. In addition, chronic musculoskeletal pain has been associated with previous history of a fall  and an increased occurrence of future falls . Musculoskeletal pain in older adults is common and debilitating, with one in five older adults reporting that this pain interferes with normal life . The Australian Institute of Health and Welfare reported that chronic back problems affect 27% of people aged between 65 and 74 years in Australia . Furthermore, the severity and number of chronic musculoskeletal pain sites are associated with reduced balance performance and falls risk .
Manual therapy is a commonly used intervention for musculoskeletal pain, particularly low back pain (LBP)  and neck pain . Two systematic reviews have found emerging evidence that manual therapy may improve balance [13, 14]. These systematic reviews included studies of asymptomatic and symptomatic participants with outcomes limited to falls and balance. They reported that improvements in balance were associated with reduction in pain intensity in symptomatic, but not in asymptomatic, participants. No meta-analyses were conducted in these systematic reviews, due to heterogeneity of the participants and outcome measures and the low methodological quality of the trials. An updated and expanded review of published studies in the literature needs to be conducted examining participants with pain.
Stability is a term that is used to denote how balance is controlled. If standing stability is perturbed, for example, various neurophysiological protective mechanisms need to be actioned in order to preserve whole body centre of mass within the base of support – that is, to preserve balance. Balance control deficits are associated with decreased stability. Clinical assessments of stability include tests of physical performance such as the sit-to-stand test or one-legged standing – which test balance control mechanisms. Balance impairment is a risk factor for falls as is gait impairment . If pain reduction is associated with stability improvement, it is important that future trials assessing manual therapy for pain management are of high quality and include relevant functional physical performance measures  to assess these changes, even beyond static balance.
Therefore, the objective of this study was to examine the effectiveness of manual therapies for musculoskeletal pain on stability (including balance, physical performance and fear of falls). For the purposes of this review, reduced stability was measured and defined by: experiencing a fall; increased self-reported fear of falling; and reduced performance on objective measures of mobility and balance. This provides important information for researchers conducting future trials of manual therapies for musculoskeletal pain using clinical or objective static and dynamic stability outcome measures.
Types of studies
Included in this review were any controlled trials (randomised, quasi-randomised and non-randomised trials). Retrospective study designs, cohort studies, case reports, case series, commentaries, letters to the editor and expert opinions were excluded. Only English language studies were included.
Types of participants
Participants in studies that met the inclusion criteria reported musculoskeletal pain of the spine or extremities. Diagnoses included, but were not limited to, neck pain, LBP, spinal pain, non-specific joint pain, fibromyalgia, arthritis, osteoarthritis (OA), disc herniation or any other bodily pain affecting the spine or extremities. Pain from multiple bodily sites was included. Diagnoses of musculoskeletal pain with radiating symptoms into the extremities, such as sciatica, were also included. Non-musculoskeletal pains such as that arising from referred visceral pain, malignancy, or nervous system pathology were excluded. Participants without pain, such as healthy participants were excluded. While stability and falls risk is predominantly of concern in older adults, in order to increase the reach of this review, any participants over the age of 18 were included.
Types of interventions and comparisons
Studies using interventions were included if they comprised at least one component of manual therapy. Manual therapies involving manipulation (high velocity, low amplitude thrust techniques to improve joint movement), mobilisation (low velocity, low-to-high amplitude non-thrust techniques to improve joint movement), or massage (pressure and movement techniques to muscles and other soft tissues) were included. Trials of manual therapy in combination with other therapies, such as exercise, were also included. Comparison groups consisting of placebo, sham therapy, no treatment (wait-list control), and any other type of active intervention were included. All comparison interventions were pooled for meta-analysis, as there were not sufficient numbers of each individual intervention (eg. placebo) for comparison.
Types of outcome measures
Outcome measures in studies that met the inclusion criteria consisted of number of falls, physical performance on clinical balance measures (such as sit-to-stand, gait speed, timed up and go (TUG) test), objective balance measures (including changes in centre of pressure on a force plate), and subjective measures of stability including psychological concerns of falling (such as fear of falls or falls efficacy questionnaires).
Electronic databases searched in Jan 2018 were The Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane database of systematic reviews, PubMed, EMBASE, CINAHL, and Index to Chiropractic Literature. Keywords consisted of terms related to “manual therapy” combined with “falls” OR “balance” OR “physical performance” AND “musculoskeletal pain” (A full list of search terms is available from the corresponding author upon request). Search terms were modified for each database, and appropriate subheadings were used for each database searched.
Study selection and data extraction
After duplicates were removed, two reviewers independently screened all titles and abstracts identified from the electronic database searches. Authors identified which studies should be further examined for inclusion into the review. Full text records were sourced, and two reviewers independently examined each record. Any disagreements between review authors were resolved by a third reviewer. Data extraction of included studies was carried out by at least two authors independently. Disagreements were resolved through consultation and involved a third reviewer if necessary.
Risk of bias
Risk of bias was assessed using the 12-item Cochrane Risk of Bias assessment  by two authors independently and any discrepancies between authors were resolved through consensus.
Studies selected for meta-analysis were those that comprised outcome measures utilised by more than two studies. Meta-analysis was performed in Review Manager 5.3. Short-term outcomes were those classified as immediate follow-up to 3 months. Long term outcomes were classified as greater than 3 months. Authors were contacted to access raw-data if there was insufficient detail in the published manuscript. Studies that were not able to be included in meta-analysis were included in the descriptive synthesis. Due to the high levels of heterogeneity between studies, a random effects model was used for all meta-analyses . Heterogeneity in meta-analysis was measured with i2.
Of 2509 citations reviewed, 150 were assessed for full text eligibility, 124 were excluded leaving 26 studies for inclusion [18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43] (Fig. 1). One hundred and twenty-four were excluded with reasons provided, which generally consisted of not including manual therapies as interventions, not including appropriate outcome measures, and study design. A list of reasons for exclusion can be given by contacting the authors.
Musculoskeletal pain diagnoses consisted of knee OA, hip OA, knee or hip OA, LBP, neck pain, knee pain, fibromyalgia, ankle arthropathy, and post-vertebral fracture (Table 1). Manual therapies consisted of manipulation [20, 30, 31, 36, 37, 39, 43], mobilisation [22, 28, 30, 31, 37, 39, 43] and massage [18,19,20,21,22, 26, 28, 29, 33, 37,38,39,40, 42] (Table 1).
Exercise was the most common intervention that was compared with manual therapy (Table 1) Exercise was prescribed as part of individual supervised programs [18, 21, 26, 27, 31,32,33, 36, 38, 40, 42], home exercise programs [25, 28, 29, 35], or a combination of supervised and home exercises . Comparison interventions involved no treatment [22, 34, 39, 41], patients continuing with usual care , and sham interventions (detuned ultrasound [20, 21, 24, 30], sub-therapeutic ultrasound , or manipulative ‘set-up’ without thrust or mobilisation ).
Outcome measures consisted of clinical balance measures (gait speed, TUG, sit-to-stand, step test), balance performance (static balance, modified Schober’s test, force place centre of pressure, postural stability and Romberg’s) (Table 1). No studies that met the inclusion criteria were found that measured the number of falls, or psychological concerns of falling.
Studies selected for meta-analysis were those that comprised outcome measures utilised by more than two studies. These outcomes were gait speed, TUG test, step test and sit-to stand test.
Studies not included in meta-analysis were those examining balance [24, 27, 35, 36, 38,39,40, 43] (due to the heterogeneity of the balance measurements) and a further two studies because their published data were not in a format appropriate for meta-analysis (displayed in a graph  and median and interquartile ranges of non-normative data ). Authors were contacted for raw-data and did not respond. One study  was partially included in meta-analysis. It was included in the gait speed meta-analysis but could not be included in the sit-to-stand meta-analysis because this study measured the time taken to sit-to-stand five times, unlike the other studies which measured the number of stands in 30 s. While not included in meta-analyses, all these studies are included in the descriptive synthesis together with the other studies.
Clinical balance measures
Gait speed improved by 0.09 m/s (95%CI 0.04, 0.13). However, there was one study that was not included in meta-analysis  that compared manual therapy to exercise, and found no significant difference in gait speed following manual therapies with home exercise versus home exercise alone in short-term follow-up.
Likewise, interventions including manual therapies found a significant improvement in TUG test scores of − 0.53 s (95%CI -0.99,-0.07), in the short but not long-term follow-up. However, there was one study that was not included in meta-analysis  that did not find any significant difference between combined manual therapy and exercise vs exercise alone on the get up and go test (a physical performance test similar to the TUG) in short-term follow-up.
There was a high level of heterogeneity in the studies (gait speed i2 = 54% p = 0.04, TUG i2 = 52% p = 0.06)). This heterogeneity was largely driven from the study by Fitzgerald and colleagues . Removing this study from the meta-analyses, gait speed remained significant, while TUG became non-significant. Due to all studies having high levels of clinical heterogeneity, it was decided to leave the Fitzgerald and colleagues’ study in the meta-analysis. With such high levels of heterogeneity, all meta-analyses results should be interpreted with caution, and more research needs to be conducted to determine the short-term benefits of manual therapy compared to other interventions.
There was no significant difference between studies consisting of manual therapies compared to other interventions for the sit-to-stand test or step test.
Objective balance measures
Eight studies examining balance measured objective balance [24, 27, 35, 36, 38,39,40, 42]. These studies were either too heterogeneous in the parameters analysed or there was insufficient reporting on the calculations used, to compare any of them in a meta-analysis.
Seven of these eight studies [24, 27, 35, 36, 39, 40, 42] used measures of pain perception and balance as an outcome of an intervention for musculoskeletal pain and recorded a reduction in pain perception as a result of the intervention. Note that Trampas and colleagues  used pain pressure threshold of muscular trigger points, not pain perception per se, as the outcome measure. Five studies noted an associated improvement in balance [35, 36, 39, 40, 42].
Risk of bias
Except for performance bias, the overall analysis of risk of bias found the studies to be of a generally low or unclear level of bias (Fig. 4).
The risk of selection bias was low with: 18/26 papers using random sequence generation in their methodology; 15/26 papers reported using allocation concealment; and group similarity at baseline found in 19/26 papers. There was blinding of participants in only 4/26 papers; only 1/26 that blinded providers; 11/26 reporting on co-interventions; and 14/26 reporting on compliance.
Risk of detection bias was low with: blinding of outcome assessment in 20/26 papers; and timing of outcome assessments 21/26. With respect to attrition bias, incomplete outcome data and drop outs were reported in 20/26 studies and these were deemed to be at acceptable levels (< 20%). Intention to treat analysis was reported in 16/26 and unclear in 7/26 studies. Reporting bias (selective reporting) was unclear in 19/26 papers, with only 5/26 with published protocols or trial registration that could be sourced for comparison with the published results. Fifteen of 26 papers declared no conflicts of interest (other bias), however, in all the other studies possible conflicts and funding sources were not declared or it was unclear whether they could be a source of bias.
This systematic review aimed to explore the possible effect/s of manual therapy on various measures of balance and stability in people with musculoskeletal pain. Improvement in clinical balance measures were reported in studies comparing manual therapy in the short-term, but not at long-term follow-up. Likewise, objective balance measures showed improvements with interventions consisting of manual therapies in 5/8 studies. The most common presenting complaints included lower limb OA and LBP. Risk of bias was low across all reported criteria except for practitioner and participant blinding. It is noted that blinding of participants and providers is difficult and often not possible for providers of manual therapies.
Short-term follow-up on gait speed showed significant improvements associated with manual therapy compared to other interventions. Clinically meaningful change to gait speed has been previously calculated as a change larger than 0.05 m/s (indicating small change) and 0.1 m/s (indicating substantial change) . This meta-analysis found that short-term interventions consisting of manual therapy, compared to other interventions, had a mean improvement of 0.09 m/s (95%CI 0.04–0.13). This indicates a relatively substantial improvement in gait speed, compared to the other interventions. However, these results should be interpreted with caution as there was a high level of statistical heterogeneity (i2 = 54%). Likewise, in short-term follow-up, manual therapy compared to other interventions showed a statistically significant improvement in TUG (mean improvement of − 0.53 s (95%CI -0.99—0.07). However, this improvement is significantly lower than the minimum clinically important difference of 3.4 s . Furthermore, the study by Cortés Godoy and colleagues  (not included in the meta-analysis) did not find any significant difference between combined manual therapy and exercise and exercise alone on the get up and go test (a physical performance test similar to TUG) in short-term follow-up. Again, the heterogeneity in this meta-analysis was high (i2 = 52%). Therefore, we stress that these results are preliminary and should be interpreted with caution.
Falls are much more prevalent in older people with pain than in those without pain . Recent epidemiological data out of Europe shows that chronic musculoskeletal pain is very frequent in older adults . Therefore, any intervention that reduces pain intensity should be accompanied by a reduction in the rate of falls in older people. Further theoretical neuro-physiological associations between manual therapy and improved stability may be considered hypothetical as there is limited evidence on the mechanisms underlying the role of manual therapy on postural stability.
This systematic review had several strengths. These included capturing a broad range of studies measuring stability outcomes, across a range of musculoskeletal conditions, and types of manual therapies. This broad approach outlined clinically relevant evidence that may help to inform future studies of manual therapies with a suggestion to include clinical outcome measures beyond pain that also capture stability. Furthermore, this study used the Cochrane protocol to maintain scientific rigor.
This study also suffers from several weaknesses. We included studies based on diverse outcome measures which had high levels of heterogeneity across study design and data analysis, particularly co-interventions and comparison interventions. The inclusion of heterogeneous outcome measures meant that it was only possible to compare the studies in a narrative synthesis. Furthermore, this systematic review was not able to capture all potential modifiers or factors that may be associated with stability such as specific classifications of musculoskeletal conditions (eg OA, myofascial pain syndromes, biomechanical joint dysfunction), affected bodily regions (extremities and spinal), chronicity of these conditions (acute, subacute or chronic), participants’ response to therapies in isolation and in combination, and responses to therapies in the short, medium and long-term.
In analysing all the studies included in this review, we did not find a clear association between significant pain reduction and balance. Part of the explanation for this lack of association may be the heterogeneity of the conditions being investigated, particularly the site of pain. It is possible that pain reduction is driving some of the improvements in the clinical testing of stability, in particular gait speed as well as in objective static and dynamic balance testing.
Further prospective studies are recommended to explore if manual therapy should be provided alone or as part of other interventions, and at what point manual therapy should be transitioned to more active interventions in the longer term. For example, if a patient is unable to exercise because of a painful musculoskeletal condition, is there a possible benefit in initially managing the condition with passive manual therapies to decrease their pain so that they might transit to appropriate exercise therapy? This is particularly important for studies in older populations where pain is a barrier to undertaking an exercise plan . The effects of treatment dose and duration also need to be explored, as higher doses of manual therapy or more extended treatment regimens may have different relationships to pain reduction and possible improvement in postural or dynamic stability. Finally, this review recommends that studies of interventions for musculoskeletal pain should include outcome measures of stability, particularly in studies including older people.
Given the substantial burden of illness caused by falls in our ageing population a better understanding of how to modify risk factors including gait speed via appropriate management strategies requires further exploration.
Availability of data and materials
The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
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Kendall, J.C., Vindigni, D., Polus, B.I. et al. Effects of manual therapies on stability in people with musculoskeletal pain: a systematic review. Chiropr Man Therap 28, 13 (2020). https://doi.org/10.1186/s12998-020-0300-9
- Manual therapy
- Systematic review