Cartwright N. Are RCTs the gold standard? BioSocieties. 2007;2:11–20. doi:10.1017/S1745855207005029.
Rothwell P. External validity of randomised controlled trials: “To whom do the results apply?”. Lancet. 2005;365(9453):82–93.
Keech A, Gebski V, Pike R. Interpreting and reporting clinical trials. A guide to the CONSORT statement and the principles of randomised controlled trials. Sydney: MJA Books, Australasian Medical Publishing Company; 2007.
Moher D, Jones A, Lepage L, for the CONSORT Group. Use of the CONSORT Statement and quality of reports of randomised trials: A comparative before-and after-evaluation. JAMA. 2001;285(15):1992–5.
Altman D, Schulz K, Moher D, Egger M, Davidoff F, Elbourne D, Gotzsche P, Lang T, for the CONSORT Group. The revised CONSORT statement for reporting randomized trials: Explanation and elaboration. Ann Intern Med. 2001;134(8):663–94.
Begg C, Cho M, Eastwood S, Horton R, Moher D, Olkin I, Pitkin R, Rennie D, Schulz K, Simel D, et al. Improving the quality of reporting of randomised controlled trials: the CONSORT statement. JAMA. 1996;276(8):637–9.
Péron J, Pond GR, Gan HK, Chen EX, Almufti R, Maillet D, et al. Quality of reporting of modern randomized controlled trials in medical oncology: a systematic review. J Natl Cancer Inst. 2012;104(13):982–9.
Ntala C, Birmpili P, Worth A, Anderson NH, Sheikh A. The quality of reporting of randomised controlled trials in asthma: Systematic review protocol. Prim Care Respir J. 2013;22(1):S1–PS8.
Borg-Debono V, Zhang S, Ye C, Paul J, Arya A, Hurlburt L, Murthy Y, Thabane L. The quality of reporting of RCTs used within a postoperative pain management meta-analysis, using the CONSORT statement. BMC Anesthesiol. 2012;12:13.
Plint AC, Moher D, Morrison A, Schulz KF, Altman DG, Hill C, Gaboury I. Does the CONSORT checklist improve the quality of reports of randomised controlled trials? A systematic review. Med J Aust. 2006;185(5):263–7.
The CONSORT 2010 Statement [http://www.consort-statement.org/consort-2010].
Boutron I, Moher D, Altman DG, Schulz KF, Ravaud P, for the CONSORT Group. Extending the CONSORT Statement to randomized trials of nonpharmacologic treatments: Explanation and elaboration. Ann Intern Med. 2008;148:295–309.
Schulz KF, Altman DG, Moher D, for the CONSORT Group. CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials. Br Med J. 2010;340(c332):698–702.
Tiruvoipati R, Balasubramanian SP, Atturu G, Peek GJ, Elbourne D. Improving the quality of reporting randomized controlled trials in cardiothoracic surgery: The way forward. J Thorac Cardiovac Surg. 2006;132(2):233–40.
Partsinevelou A, Zintzaras E. Quality of reporting of randomized controlled trials in polycystic ovary syndrome. Trials. 2009;10:106.
Chen B, Liu J, Zhang C, Li M. A retrospective survey of quality of reporting on randomized controlled trials of metformin for polycystic ovary syndrome. Trials. 2014;15:128.
Kim KH, Kang JW, Lee MS, Lee J-D. Assessment of the quality of reporting for treatment components in Cochrane reviews of acupuncture. r Open. 2014;4:e004136.
Rios LP, Odueyungbo A, Moitri MO, Rahman MO, Thabane L. Quality of reporting of randomized controlled trials in general endocrinology literature. J Clin Endocr Metab. 2008;93:3810–6.
Lu L, Luo G, Xiao F. A retrospective survey of the quality of reports and their correlates among randomised controlled trials of immunotherapy for Guillian-Barre syndrome. Immunotherapy. 2013;5(8):829–36.
Bo C, Xue Z, Yoi G, Zelin C, Yang B, Zixu W, Yajun W. Assessing the quality of reports about randomized controlled trials of acupuncture treatment on Diabetic Peripheral Neuropathy. Plos ONE. 2012;7(7):e38461.
Sjögren P, Halling A. Quality of reporting randomised clinical trials in dental and medical research. Br Dent J. 2002;192(2):100–4.
Zhuang L, He J, Zhuang X, Lu L. Quality of reporting on randomized controlled trials of acupuncture for stroke rehabilitation. BMC Compl Alternative Med. 2014;14:151.
DeMauro SB, Giaccone A, Kirpalani H, Schmidt B. Quality of reporting of neonatal and infant trials in high-impact journals. Pediatrics. 2011;128:e639.
Montori VM, Alonso-Coello P, Wang YG, Bhagra S. Systematic evaluation of the quality of randomized controlled trials in Diabetes. Diabetes Care. 2006;29(8):1833–8.
Moberg-Mogren E, Nelson DL. Evaluating the quality of reporting occupational therapy randomized controlled trials by expanding the CONSORT criteria. Am J Occup Ther. 2006;60(2):226–35.
Adetugbo K, Williams H. How well are randomized controlled trials reported in the dermatology literature? Arch Dermatol. 2000;136(3):381–5.
Karpouzis F, Brown BT, Kalamir A, Pribicevic M, Bonello R. Quality of reporting of randomized controlled trials in chiropractic using the CONSORT checklist: A protocol for a review. Chiropr J Aust. 2016;44(1):17–32.
Christensen MG, Kerkoff D, Kollasch MW. Job Analysis of Chiropractic: A Project Report, Survey Analysis, and Summary of the Practice of Chiropractic within the United States. Greeley, Colo: National Board of Chiropractic Examiners; 2000.
Brennan GP, Fritz JM, Hunter SJ, Thackeray A, Delitto A, Erhard RE. Identifying subgroups of patients with acute/subacute “nonspecific” low back pain: Results of a randomized clinical trial. Spine. 2006;31(6):623–31.
Juni P, Battaglia M, Nuesch E, Hammerle G, Eser P, van Beers R, Vils D, Bernhard J, Ziswiler H-R, Reichenbach S, et al. A randomised controlled trial of spinal manipulative therapy in acute low back pain. Ann Rheum Dis. 2008;68:142–27.
Leaver AM, Maher CG, Herbert RD, Latimer J, McAuley JH, Jull G, Refshauge KM. A randomized controlled trial comparing manipulation with mobilization for recent onset neck pain. Arch Phys Med Rehabil. 2010;91:1313–8.
Eisenberg DM, Post DE, Davis RB, Connelly MT, Legedza ATR, Hrbek AL, Prosser LA, Buring JE, Inui TS, Cherkin DC. Addition of choice of complementary therapies to usual care for acute low back pain: a randomized controlled trial. Spine. 2007;32(2):151–8.
Rosner AL, Conable KM, Edelmann T. Influence of foot orthotics upon duration of effects of spinal manipulation in chronic back pain patients: A randomised clinical trial. J Manipulative Physiol Ther. 2014;37:124–40.
Petersen T, Larsen K, Nordsteen J, Olsen S, Fournier G, Jacobsen S. The McKenzie Method compared with manipulation when used adjunctive to information and advice in low back pain patients presenting with centralization or peripheralization: A randomized controlled trial. Spine. 2011;36(24):1999–2010.
Parkin-Smith GF, Norman IJ, Briggs E, Angier E, Wood TG, Brantingham JW. A structured protocol of evidence-based conservative care compared with usual care for acute nonspecific low back pain: A randomized clinical trial. Arch Phys Med Rehabil. 2012;93:11–20.
Poulsen E, Hartvigsen J, Christensen HW, Roos EM, Vach W, Overgaard S. Patient education with or without manual therapy compared to a control grou. in patients with osteoarthritis of the hip. A proof-of- principle three-arm parallel group randomized clinical trial. Osteoarthritis Cartilage. 2013;21:494e1503.
Piggott M, McGee H, Feuer D. Has CONSORT improved the reporting of randomized controlled trials in the palliative care literature? A systematic review. Palliat Med. 2004;18(1):32–8.
Huwiler-Muntener K, Juni P, Junker C, Egger M. Quality of reporting of randomized trials as a measure of methodologic quality. JAMA. 2002;287(21):2801–4.
Lai R, Chu R, Fraumeni M, Thabane L. Quality of randomized controlled trials reporting in the primary treatment of brain tumors. J Clin Oncol. 2006;24(7):1136–44.
Moher D, Schulz KF, Altman D, for the CONSORT Group. The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials. BMC Med Res Method. 2001;1:2.
Boutron I, Moher D, Altman D, Schulz K, Ravaud P, for the CONSORT Group. Methods and processes of the CONSORT group: example of an extension for trials assessing nonpharmacologic treatments: explanation and elaboration. Ann Intern Med. 2008;148(4):295–309.
Rubinstein SM, van Middelkoop M, Assendelft WJ, de Boer MR, van Tulder MW: Spinal manipulative therapy for chronic low-back pain. Cochrane Database of Syst Rev 2011, Issue 2(Art. No.: CD008112).
Bhandari M, Richards RR, Sprague S, Schemitsch EH. The quality of reporting of randomized trials in the journal of bone and joint surgery from 1988 through 2000. J Bone Joint Surg Am. 2002;84(3):388–96.
Lexchin J, Bero LA, Djulbegovic B, Clark O. Pharmaceutical industry sponsorship and research outcome and quality: systematic review. Br Med J. 2003;326(7400):1167–70.
Okike K, Kocher MS, Mehlman CT, Bhandari M. Industry-sponsored research. Injury. 2008;39(6):666–80.
Djulbegovic B, Lacevic M, Cantor A, Fields KK, Benett CL, Adams JR, Kuderer NM, Lyman GH. The uncertainty principle and industry-sponsored research. Lancet. 2000;356(9230):635–8.
Easterbrook PJ, Berlin JA, Gopalan R, Matthews DR. Publication Bias in clinical research. Lancet. 1991;337(8746):867–72.
Bourgeois FT, Murthy S, Mandl KD. Outcome reporting among drug trials registered in ClinicalTrials.gov. Ann Intern Med. 2010;153(3):158–66.
Mansholt BA, Stites JS, Derby DC, Boesch RJ, Salsbury SA. Essential literature for the chiropractic profession: a survey of chiropractic research leaders. Chiropr Man Therap. 2013;21:33.
Coulter ID, Hurwitz EL, Adams AH, Genovese BJ, Hays R, Shekelle PG. Patients using chiropractors in North America: who are they, and why are they in chiropractic care? Spine (Phila Pa 1976). 2002;27:291–6.
Davis MA, Davis AM, Luan J, Weeks WB. The supply and demand of chiropractors in the United States from 1996 to 2005. Altern Ther Health Med. 2009;15(3):36–40.
Moseley AM, Herbert RD, Maher CG, Sherrington C, Elkins MR. Reported quality of randomized controlled trials of physiotherapy interventions has improved over time. J Clin Epidemiol. 2011;64(6):594–601.
Rubinstein SM, van Eekelen R, Oosterhuis T, de Boer MR, Ostelo RWJG, van Tulder MW. The risk of bias and sample size of trials of spinal manipulative therapy for low back and neck pain: analysis and recommendations. J Manipulative Physiol Ther. 2014;37(8):523–41.
DeAngelis C, Drazen J, Frizelle F, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke A, et al. Clinical trial registration: a statement from the International Committee of Medical Journal Editors. JAMA. 2004;292(11):1363–4.
Moher D, Schulz K, Altman D. The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomiized trials. JAMA. 2001;285(15):1987–91.
Maiers M, Bronfort G, Evans R, Hartvigsen J, Svendsen K, Bracha Y, Schulz C, Schulz K, Grimm R. Spinal manipulative therapy and exercise for seniors with chronic neck pain. Spine J. 2014;14(9):1879–89.
Brantingham JW, Parkin-Smith GF, Cassa TK, Globe GA, Globe D, Pollard H, deLuca K, Jensen M, Mayer S, Korporaal C. Full kinetic chain manual and manipulative therapy plus exercise compared with targeted manual and manipulative therapy plus exercise for symptomatic osteoarthritis of the hip: a randomized controlled trial. Arch Phys Med Rehabil. 2012;93:259–67.
Haas M, Vavrek D, Peterson D, Polissar N, Neradilek MB. Dose-response and efficacy of spinal manipulation for care of chronic low back pain: a randomized controlled trial. Spine J. 2014;14:1106–16.
Pollard H, Ward G, Hoskins W, Hardy K. The effect of a manual therapy knee protocol on osteoarthritic knee pain: a randomised controlled trial. J Can Chiropr Assoc. 2008;52(4):229–42.
Hondras MA, Long CR, Cao Y, Rowell RM, Meeker WC. A randomised controlled trial comparing 2 types of spinal manipulation and minimal conservative medical care for adults 55 years and older with subacute or chronic low back pain. J Manipulative Physiol Ther. 2009;32(5):330–43.
Roy RA, Boucher JP, Comtois AS. Heart rate variability modulation after manipulation in pain free patients vs patients in pain. J Manipulative Physiol Ther. 2009;32(4):277–86.
Evans R, Bronfort G, Schulz C, Maiers M, Bracha Y, Svendsen K, Grimm J, Richard , Garvey T, Transfeldt E. Supervised exercise with and without spinal manipulation performs similarly and better than home exercise for chronic neck pain: a randomized controlled trial. Spine. 2012;37(11):903–14.
Bronfort G, Maiers MJ, Evans RL, Schulz CA, Bracha Y, Svendsen KH, Grimm J, Richard H., Owens JEF, Garvey TA, Transfeldt EE. Supervised exercise, spinal manipulation, and home exercise for chronic low back pain: a randomized clinical trial. Spine J. 2011;11:585–98.
McMorland G, Suter E, Casha S, du Plessis SJ, Hurlbert JR. Manipulation or microdiskectomy for sciatica? a prospective randomized clinical study. J Manipulative Physiol Ther. 2010;33(8):576–84.
Srbely JZ, Vernon H, Lee D, Polgar M. Immediate effects of spinal manipulative therapy on regional antinociceptive effects in myofascial tissues in healthy young adults. J Manipulative Physiol Ther. 2013;36(6):333–41.
Walker BF, Hebert J, Stomski NJ, Losco B, French S. Short-term usual chiropractic care for spinal pain: a randomized controlled trial. Spine (Phila PA 1976). 2013;38(24):2071–8.
Walker BF, Hebert JJ, Stomski NJ, Clarke BR, Bowden RS, Losco BM, French SD. Outcomes of usual chiropractic. The OUCH randomized controlled trial of adverse events. Spine (Phila PA 1976). 2013;38(20):1723–9.
Holt K, Beck R, Sexton S, Taylor HH. Reflex effects of a spinal adjustment on blood pressure. Chiropr J Aust. 2010;40(3):95–9.
Engel RM, Vemulpad SR. The effect of combining spinal manipulation with exercise on the respiratory function of normal individuals: a randomized control trial. J Manipulative Physiol Ther. 2007;30(7):509–13.
Ward J, Coats J, Tyer K, Weigand S, Williams G. Immediate effects of anterior upper thoracic spine manipulation on cardiovascular response. J Manipulative Physiol Ther. 2013;36(2):101–10.
Stochkendahl MJ, Christensen HW, Vach W, Høilund-Carlsen PF, Haghfelt T, Hartvigsen J. Chiropractic treatment vs self-management in patients with acute chest pain: a randomized controlled trial of patients without acute coronary syndrome. J Manipulative Physiol Ther. 2012;35:7–17.
Goertz CM, Long CR, Hondras MA, Petri R, Delgado R, Lawrence DJ, Owens JEF, Meeker WC. Adding chiropractic manipulative therapy to standard medical care for patients with acute low back pain. Spine. 2013;38(8):627–34.
Muller R, Giles LG. Long-term follow-up of a randomized clinical trial assessing the efficacy of medication, acupuncture, and spinal manipulation for chronic mechanical spinal pain syndromes. J Manipulative Physiol Ther. 2005;28(1):3–11.
Bishop PB, Quon JA, Fisher CG, Dvorak MFS. The chiropractic hospital-based interventions research outcomes (CHIRO) study: a randomized controlled trial on the effectiveness of clinical practice guidelines in the medical and chiropractic management of patients with acute mechanical low back pain. Spine J. 2010;10:1055–64.
Shearar KA, Colloca CJ, White HL. A randomized clinical trial of manual versus mechanical force manipulation in the treatment of sacroiliac syndrome. J Manipulative Physiol Ther. 2005;28:493–501.
Wilkey A, Gregory M, Byfield D, McCarthy P. A comparison between chiropractic management and pain clinic management for chronic low-back pain in a national health service outpatient clinic. J Altern Complement Med. 2008;14(5):465–73.
Beyerman KL, Palmerino MB, Zohn LE, Kane GM, Foster KA. Efficacy of treating low back pain and dysfunction secondary to osteoarthritis: chiropractic care compared with moist heat alone. J Manipulative Physiol Ther. 2006;29:107–14.
Santilli V, Beghi E, Finucci S. Chiropractic manipulation in the treatment of acute back pain and sciatica with disc protrusion: a randomized double-blind clinical trial of active and simulated spinal manipulations. Spine J. 2006;6:131–7.
Teodorczyk-lnjeyan JA, Injeyan SH, Ruegg R. Spinal manipulative therapy reduces inflammatory cytokines but not substanc P production in normal subjects. J Manipulative Physiol Ther. 2006;29:14–21.
Palmgren PJ, Sandstrom PJ, Lundqvist FJ, Heikkila H. Improvement after chiropractic care in cervicocephalic kinesthetic sensisibility and subjective pain intensity in patients with nontraumatic chronic pain. J Manipulative Physiol Ther. 2006;29:100–6.
Saayman L, Hay C, Abrahamse H. Chiropractic manipulative therapy and low-level laser therapy in the management of cervical facet dysfunction: a randomised controlled study. J Manipulative Physiol Ther. 2011;34:153–63.
Puhl AA, Injeyan SH. Short-term effects of manipulation to the upper thoracic spine of asymptomatic subjects on plasma concentrations of epinephrine and norepinephrine-a randomized and controlled observational study. J Manipulative Physiol Ther. 2012;35(3):209–15.
Schenk R, Dionne C, Simon C, Johnson R. Effectiveness of mechanical diagnosis and therapy in patients with back pain who meet a clinical prediction rule for spinal manipulation. J Man Manip Ther. 2012;20(1):43–9.
Schulz C, Leininger B, Evans R, Vavrek D, Peterson D, Haas M, Bronfort G. Spinal manipulation and exercise for low back pain in adolescents: study protocol for a randomized controlled trial. Chiropr Man Therap. 2014;22(21):1–9.
Schneider MJ, Brach J, Irrgang JJ, Abbott KV, Wisniewski SR, Delitto A. Mechanical vs manual manipulation for low back pain: an observational cohort study. J Manipulative Physiol Ther. 2010;33(3):193–200.
Miller JE, Newell D, Bolton JE. Efficacy of chiropractic manual therapy on infant colic: A pragmatic single-blind, randomized controlled trial. J Manipulative Physiol Ther. 2012;35:600–7.
Goertz CM, Salsbury SA, Vining RD, Long CR, Andresen AA, Jones ME, Lyons KJ, Hondras MA, Killinger LZ, Wolinsky FD, et al. Collaborative care for older adults with low back pain by family medicine physicians and doctors of chiropractic (COCOA): study protocol for a randomized controlled trial. Trials. 2013;14:18. doi:10.1186/1745-6215-14-18.
Brantingham JW, Globe GA, Cassa TK, Globe D, de Luca K, Pollard H, Jensen ML, Bates C, Jensen M, Mayer S, et al. A single-group pretest posttest design using full kinetic chain manipulative therapy with rehabilitation in the treatment of 18 patients with hip osteoarthritis. J Manipulative Physiol Ther. 2010;33(6):445–57.
Brantingham JW, Globe GA, Jensen ML, Cassa TK, Globe D, Price JL, Mayer SN, Lee FT. A feasibility study comparing two chiropractic protocols in the treatment of patellofemoral pain syndrome. J Manipulative Physiol Ther. 2009;32(7):536–48.
Rowe DE, Feise RJ, Crowther ER, Grod JP, Menke MJ, Goldsmith CH, Stoline MR, Souza TA, Kambach B. Chiropractic manipulation in adolescent idiopathic scoliosis: a pilot study. Chiropr Osteopat. 2006;14(15):1–10.
UK BEAM Trial Team: United Kingdom back pain exercise and manipulation (UK BEAM) randomised trial: effectiveness of physical treatments for back pain in primary care. BMJ online 2004.
Thorman P, Dixner A, Sundberg T. Effects of chiropractic care on pain and function in patients with hip osteoarthritis waiting for arthroplasty: a clinical pilot trial. J Manipulative Physiol Ther. 2010;33(6):438–44.
Hawk C, Pfefer MT, Strunk R, Ramcharan M, Uhl N. Feasibility study of short-term effects of chiropractic manipulation on older adults with impaired balance. J Chiropr Med. 2007;6:121–31.
Westrom KK, Maiers MJ, Evans RL, Bronfort G. Individualized chiropractic and integrative care for low back pain: the design of a randomized clinical trial using a mixed-methods approach. Trials. 2010;8(11):24.
Engel R, Vemulpad SR, Beath K. Short-term effects of a course of manual therapy and exercise in people with moderate chronic obstructive pulmonary disease: a prelimary clinical trial. J Manipulative Physiol Ther. 2013;36(8):490–6.
Botelho MB, Andrade BB. “Effect of cervical spine manipulative therapy on judo athletes’ grip strength”. J Manipulative Physiol Ther. 2012;35(1):38–44.
Strunk RG, Hondras Maria A. A feasibility study assessing manual therapies to different regions of the spine for patients with subacute or chronic neck pain. J Chiropr Med. 2008;7:1–8.
Eisenberg DM, Buring JE, Hrbek AL, Davis RB, Connelly MT, Cherkin DC, Levy DB, Cunningham M, O’Connor B, Post DE. A model of integrative care for low-back pain. J Altern Complement Med. 2012;18(4):354–62.
Vavrek D, Haas M, Peterson D. Physical examination and self-reported pain outcomes from a randomized trial on chronic cervicogenic headache. J Manipulative Physiol Ther. 2010;33:338–48.
Hurwitz EL, Morgenstern H, Kominski GF, Yu F, Chiang L-M. A randomized trial of chiropractic and medical care for patients with low back pain: eighteen-month follow-up outcomes from UCLA low back pain study. Spine. 2006;31(6):611–21.