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Potential risk factors and triggers for back pain in children and young adults. A scoping review, part II: unclear or mixed types of back pain

Chiropractic & Manual Therapies volume 27, Article number: 61 (2019) Cite this article

Abstract

Background

Back pain is a global problem in terms of disability and financially, with a large burden both to the individual and to society. Back pain was previously believed to be uncommon in children. However, there is a growing body of evidence that this is not the case.

Objective

Part I of this scoping review studied risk factors of incident and episodic back pain. In this part II we aimed to identify all risk factors and triggers with unclear or mixed type back pain in young people and to identify any gaps in the literature.

Methods

A scoping review design was selected to summarise the evidence, as there are many studies on “risk factors” for back pain. The scoping review followed the PRISMSA-ScR guidelines. We considered all studies that tested potential risk factors and triggers for thoracic and/or lumbar spine pain, in children, adolescents, and young adults (≤ 24 years). PubMed and Cochrane databases were searched from inception to September 2018, to identify relevant English language articles. The results regarding potential risk factors were separated into temporal precursors and bidirectional risk factors and the studies were classified by study design.

Results

Our comprehensive search strategy identified 7356 articles, of which 83 articles were considered eligible for this review (part II). There were 53 cross-sectional studies and 30 cohort studies. Potential risk factors for back pain were: female sex, older age, later pubertal status, positive family history of back pain, increased growth, and a history of back pain, most of which are temporal precursor variables. There was limited research for the illness factors, spinal posture, and muscle endurance in the development of back pain.

Conclusion

Many of the included studies approached risk factors in similar ways and found factors that were associated with back pain but were not obvious risk factors as causality was uncertain. Future research should be more rigorous and innovative in the way that risk factors are considered. This could be through statistical approaches including cumulative exposures, or longitudinal approaches including multi-trajectory methods. Additionally, data on proposed risk factors should be collected before the onset of back pain.

Background

Back pain is a global problem in terms of disability and financial costs, with a large burden both to the individual and to society [1]. Back pain was once believed to be uncommon in young people. However there is evidence that this is not the case [2, 3]. Back pain can start during childhood or adolescence [2, 3]. Therefore, it is important not to ignore younger populations. Numerous studies have attempted to investigate a myriad of potential risk factors of back pain in children and young adults. Identifying early life factors that predispose young people to back pain in later life may help identify at-risk populations and inform future prevention strategies. Prevention of back pain in adolescence could help the prevention of back pain into adulthood [4].

Some potential risk factors definitely occur before the inception of the disease; we define these variables as temporal precursors. Temporal precursors are variables known to have a definite preceding temporal relationship with a disease (e.g., sex, age, pubertal status, family history, family socioeconomic factors, and height). Conversely, other factors studied may not have occurred prior to the onset of the disease, and they can have a bidirectional relationship with the disease of interest. If such potential risk factor is measured concurrently with back pain, then we cannot know if the potential risk factor preceded the back pain or not. Examples include body mass index (BMI), muscle endurance and flexibility, posture, physical activity behaviour, work, screen time, inadequate sleep, smoking, illnesses, and psychosocial factors.

Due to the vast number of studies on “risk factors” for back pain a two part scoping review of the literature was chosen as the best way to summarise the evidence. Part I of this scoping review (Potential risk factors and triggers for back pain in children and young adults. A scoping review, part I: incident and episodic back pain) studied risk factors of incident and episodic back pain. In Part II we aimed to identify all risk factors and triggers for back pain (unclear or mixed types of back pain) in young people and to identify any gaps in the literature. Moreover, in this second part, all eligible studies (unclear or mixed types of back pain) that tested potential risk factors of back pain and triggers of its further episodes were included.

Methods

The full methods are reported elsewhere (Potential risk factors and triggers for back pain in children and young adults. A scoping review, part I: incident and episodic back pain). However, a summary of the methods is provided below. We undertook a scoping review in accordance with reporting guidelines (PRISMA-ScR) [5]. A review protocol was not included in a registry as PROSPERO does not currently accept registrations for scoping reviews. The broad question of interest was what are the potential risk factors and potential triggers for back pain in childhood and young adulthood? ‘Back pain’ was defined as pain within the thoracic and/or lumbar areas. A search was conducted using the PubMed and Cochrane databases from inception to September 2018. The full search strategy is listed in Additional file 1. Results of the search were reported as per the PRISMA flow diagram (Fig. 1).

Fig. 1
figure 1

Final study selection flow diagram

Full size image

Eligibility criteria

We included studies that reported on potential risk factors or triggers for pain in the thoracic and/or lumbar spine (a risk factor is the cause of ‘disease’ of back pain defined as the first time they have back pain compared to a trigger, which could lead to an episode of back pain when the disorder of back pain is already established). The majority of the participants were to be less than 25 years old at baseline. The age classification is based on the MeSH definition of a young adult (19–24 years). Additionally, the contemporary definitions of adolescence includes young adulthood (10–24 years) [6]. Original peer-reviewed studies in the English language from any country of origin were included and study designs comprised retrospective, cross-sectional, and prospective observational studies. Cross-sectional studies were only included if the potential risk factors met Bradford Hill’s tenet of temporality for the study of risk factors or triggers (i.e., if the exposure was classified as a temporal precursor e.g. age) [7].

Study selection, data charting and synthesis of results

Titles, abstracts, and full-text articles were screened by one researcher (AB) twice (March 2018 and then September 2018) against the inclusion criteria. The second search identified four additional articles due to the passage of time. Another researcher (BW) verified the study selection for accuracy (titles, abstracts, and full-text screen) and full consensus was met through discussion.

Calibration of the data charting forms was conducted by two researchers (AB and CLY). One researcher (AB) piloted the form on three studies. This process was verified by another researcher (CLY). This was an iterative process in which there were many changes during each round. Any disagreements were resolved by a third researcher (BW).

Charting of data (data extraction in scoping reviews [8]) was completed by one researcher (AB) using the evidence tables. This information was checked for errors several times with an audit of all data entered with at least a week between each audit. Potential risk factors or triggers were separated into temporal precursors or potentially bidirectional risk factors. Results for the cross-sectional and prospective studies are reported together for potential risk factors that are inherently present before the back pain (temporal precursors). If a study had multiple estimates for the same risk factor the most adjusted estimate of association was extracted. Clarity of definition of back pain was assessed in each study with a summative score provided. Individual points were given if there was a clear description of the area of back pain, a clear reporting of the recall period, a clear definition of the type of back pain, and if there was an attempt to collect valid data (maximum four points).

Results

Study selection

Our database searches identified 7537 articles and a subsequent search of the relevant references lists resulted in an additional 16 articles. In all, 91 articles were considered eligible for this review. Eight studies appeared to have studied risk factors of incident back pain and back pain episodes (reported in part I). Within part II, 83 studies were included, as these failed to clearly identify whether they studied inception events or ongoing/episodes of back pain (Fig. 1).

Study characteristics and synthesis of results

Of the 83 articles included in this review, 30 (36%) were prospective cohort studies [4, 9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37]. The majority of cohort studies did not have a clear description of back pain or captured a mixture of back pain types. Thus, many studies appear to have dealt with either back pain episodes or the incidence of back pain. They only considered a limited time frame and did not report details of the previous pain-free period. Therefore, these studies could reflect a mixture of first time, recurrent, and ongoing back pain episodes.

The included studies included temporal precursor variables such as sex, age, pubertal status, family history, socioeconomic status, and height. Potential bidirectional variables included BMI, muscle endurance and flexibility, posture, physical activity and work, screen time, inadequate sleep, carrying bags, smoking, illnesses, and psychosocial factors. Charts of the summary of findings are reported in Additional file 2.

There were 53 cross-sectional studies included in this review [38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90]. These studies reported factors that could potentially be associated with back pain such as sex, age, pubertal status, family history, and socioeconomic status. Charts of the summary of findings are seen in Additional file 3.

Temporal precursor variables

Sex

In the 53 studies reporting on sex and back pain, 32 studies found a positive association with female sex and back pain, three studies found a higher prevalence of back pain in males, and 18 studies found no association with sex (Table 1). There was generally a positive association between female sex and back pain.

Table 1 Summary of temporal precursor variables: cross-sectional and prospective studies
Full size table

Age

In the 34 studies reporting on age and back pain (Table 1), there was generally a higher prevalence of back pain with advancing age in children towards adolescence and young adulthood.

Family history

In the 19 studies reporting on family history and back pain (Table 1), there was by and large a higher prevalence in those with a positive family history of back pain.

Socioeconomic status

In 15 studies there were inconsistent estimates of association for the relationship between socioeconomic factors and back pain. Seven studies reported positive associations between certain socioeconomic factors and back pain, whereas eight studies reported no association (Table 1).

Increased height or increased growth spurt

In the 12 studies on height or increased growth there were inconsistent estimates of association for the relationship between these and back pain (Table 1). Overall height does not appear to be a risk factor for back pain. However, the occurrence of ‘growth spurts’ has been found to be positively associated with back pain.

Pubertal status

As demonstrated in Table 1, in the six studies that reported on pubertal status and back pain, there was an association with back pain typically seen in those with an advanced pubertal status.

History of back pain

Three studies reported on history of back pain and risk of further back pain (Table 1). All studies found a positive association with odds ratios ≥2.7.

Bidirectional variables

Physical activity and work

Ten studies considered physical activity and/or work as a potential risk factor of back pain. Six studies reported that with certain types of physical activity or work there was an increased prevalence of back pain, whereas four studies found no association (Table 2). It appears certain types of work such as white-collar work or manual work, and vigorous or high levels of physical activity may be associated with back pain.

Table 2 Summary of bidirectional variables
Full size table

Psychosocial factors

In the seven studies that tested psychosocial factors as risk factors of back pain, four studies found an increased risk of back pain, while three studies found no association (Table 2). Some psychosocial factors (depression, anxiety and ‘peer problems’) were associated with back pain while internalising, anxiety sensitivity, dysfunctional coping, and catastrophizing were not associated with future back pain.

Body mass index

In the eight studies that reported on BMI and back pain (Table 2), three studies reported an increased prevalence and five studies found no association (Table 2). There were inconsistent estimates of association, with insufficient evidence to conclude that there is a relationship between BMI and back pain.

Smoking

In the six studies that reported on smoking and back pain (Table 2), all found a positive association between the two. It does appear that smoking has some relationship with back pain.

Systemic factors /illnesses

Four studies tested systemic factors or illnesses as potential risk factors of back pain. Three studies found positive associations whereas one found none (Table 2). Associations with back pain were stronger with certain systemic diseases such as having asthma, headaches, abdominal pain, and colds/minor illnesses. These may be co-morbidities to back pain, meaning that one could be a precursor to the other or they could have a common cause.

Spinal posture and sitting posture

Four studies reported on certain aspects of posture and back pain (Table 2). All four studies indicated that from a preliminary viewpoint abnormal spinal posture and certain sitting positions were associated with back pain.

Sleep

As seen in Table 2, in the three studies that reported on sleep and back pain, there was a positive association between back pain and insufficient sleep.

Flexibility

Three studies tested muscle flexibility as a risk factor for back pain (Table 2). Two studies found a positive association with decreased flexibility of hamstrings or quadriceps, and back pain, while one study found no association.

Screen time

Three studies reported inconsistent estimates of associations between screen time and back pain. One study reported a higher prevalence of back pain with increased television time, whereas two reported none (Table 2).

Backpack factors

In three studies, there were inconsistent estimates of association between backpack factors and back pain. One study of these three reported a higher prevalence of back pain with a heavier school satchel (Table 2).

Muscle endurance

In the one study that tested muscle endurance as a risk factor of back pain, it was found that those with poor back muscle endurance had a positive association with back pain (Table 2).

Discussion

Overall summary of potential risk factors from all studies

Considering the existing literature, the factors found to be likely risk factors or triggers for back pain are female sex, older age, advanced pubertal status, high growth rate, positive family history of back pain, a history of back pain, smoking, and insufficient sleep. Most of these factors are temporal precursor. Further, they are mostly biological and non-modifiable, making them ineligible targets for preventative interventions. No association or weak associations were noted with increased screen time and work. There were mixed results for muscle flexibility, socioeconomic status, backpack-related factors, anthropometric measures including height and weight, and physical activity. There was limited research for systemic/illness factors, muscle endurance, spinal posture, and sitting position (Table 3).

Table 3 Summary of Potential Risk factors
Full size table

Implications of results

Previous systematic reviews found the most likely risk factors for back pain in young people to be female sex [91,92,93], older age [91, 92, 94], advanced pubertal status [95], positive family history of back pain [96], and a previous history of back pain [93, 97]. We advanced this knowledge by further considering the temporal relationship between the risk factors and back pain and we concluded that the most likely risk factors or triggers for back pain are predominantly biological. For example, the genetic component of back pain is potentially large [98]. A systematic review found that estimates of heritability effects ranged from 21 to 67% [99]. However, environmental exposures also have an effect, so the question arises; how large is this effect? This question could be addressed through further twin control studies. Twin studies have an advantage of reducing confounding due to genetics and can be utilised to explore the potential causal pathway between environmental factors, co-morbidities and back pain [99].

Considering the strength of associations, some factors were statistically linked to back pain, but the next question arises, are they important on a clinical or individual level?

Another issue to consider is that individual associations may well be relatively weak, but it is possible that combination of factors or the addition of factors could increase the risk of back pain rather than individual factors. This idea has been proposed previously through a dynamic multifactorial and recursive model of aetiology [100]. This model emphasizes the importance of investigating intrinsic predisposing factors along with the extrinsic factors that interact together to make an individual vulnerable to injury [100]. Certain predictive risk factors could predispose individuals to back pain, and then in combination with other potentially causal risk factors, the individual could develop back pain. For example, girls (factor 1) with advanced pubertal status (factor 2) could be susceptible to back pain that is subsequently caused by vigorous physical activity (factor 3). Therefore, from a clinical perspective, it might be important to consider the person as a whole.

Limitations of the current literature

The foremost limitations of the current literature are that the majority of studies are cross-sectional, or if longitudinal, most do not start data collection before the onset of back pain. To investigate temporality, one criterion to establish causal relationships, risk factors should be captured before the inception of the disease [101]. Therefore, the conclusions of this scoping review are limited to demonstrating association and not causation. Additionally, the definitions of ‘back pain’ vary from study to study (Additional files 4 and 5), this means it is not clear whether authors are considering back pain as a disease or an episode [101], or whether they are asking about back pain currently, for the past week, for the past month, or for the past year. Although the purpose of this review was to include risk factors or triggers for pain the thoracic and/or lumbar spine, some of the included studies included spinal pain in general [9, 15, 16, 18, 35, 39, 86,87,88,89]. While other studies included back pain without a clear definition of location [22, 26, 49, 50, 56, 61, 63, 69, 70, 74, 81], and therefore it is unclear what they were looking at. As the definitions on back pain are not always clear or inconsistent it is difficult to make clear definitive statements.

Limitations of this review

A potential limitation of the validity of data collected in this scoping review is that only one researcher screened and conducted data charting. Nevertheless, articles were screened twice, by the same reviewer, and a second researcher verified the process, which is consistent with the PRISMA-ScR guidelines. Only two key databases were searched, and articles were limited to English language. Consequently, we may have missed some articles. Nevertheless, this type of literature is quite stereotyped, for which reason it is unlikely that any missing articles would be of significance.

There were some contradictory findings in our result tables. Contradictory findings often result from differences in study populations, definitions of the outcome or independent variables, and differences in data quality. However, due to the nature of scoping reviews, which lack the critical approach of systematic reviews, such contradictions cannot be interpreted. Due to the nature of conflicting data the summary of potential risk factors is indicative but not unequivocal.

Recommendations for future research

Future studies should collect data from the inception of back pain by following the population from earlier life, if searching for causes of the ‘disease’ back pain. They should additionally collect data on proposed risk factors before the onset of back pain. If studies are attempting to identify triggers of future events, back pain episodes must be separated by non-episodes.

As highlighted within this scoping review (Additional files 4 and 5), future research should ensure that data are collected with a clear definition of back pain and ideally measured through a validated questionnaire. Additionally, future research should be more innovative in the way that risk factors are considered. This could be through statistical approaches including cumulative exposures, or longitudinal approaches such as multi-trajectory methods and through the use of twin studies.

Conclusion

Many of the included studies approached identifying risk factors in similar ways and found factors that were associated with back pain but were not obvious risk factors as causality was uncertain. Obviously, the time has come to approach this problem in other ways. It is our opinion that future research should be more rigorous and innovative in the way that risk factors for back pain are considered.

Availability of data and materials

Not applicable.

Abbreviations

BMI:

Body mass index

BP:

Back pain

CI:

Confidence intervals

HR:

Hazard ratio

IRR:

Incidence rate ratio

LBP:

Low back pain

MBP:

Mid back pain

N:

Number of participants

NA:

Not applicable

OR:

Odds ratio

PR:

Prevalence ratio

RR:

Relative risk

References

  1. Hoy D, Bain C, Williams G, March L, Brooks P, Blyth F, et al. A systematic review of the global prevalence of low back pain. Arthritis Rheum. 2012;64(6):2028–37.

    PubMed  Google Scholar 

  2. Balague F, Troussier B, Salminen JJ. Non-specific low back pain in children and adolescents: risk factors. Eur Spine J. 1999;8(6):429–38.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Kjaer P, Wedderkopp N, Korsholm L, Leboeuf-Yde C. Prevalence and tracking of back pain from childhood to adolescence. BMC Musculoskelet Disord. 2011;12(1):98.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Feldman DE, Shrier I, Rossignol M, Abenhaim L. Risk factors for the development of low back pain in adolescence. Am J Epidemiol. 2001;154(1):30–6.

    Article  CAS  PubMed  Google Scholar 

  5. Tricco AC, Lillie E, Zarin W, O'Brien KK, Colquhoun H, Levac D, et al. PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med. 2018;169(7):467-73.

  6. Sawyer SM, Azzopardi PS, Wickremarathne D, Patton GC. The age of adolescence. Lancet Child Adolesc Health. 2018;2(3):223–8.

    Article  PubMed  Google Scholar 

  7. Hill AB. The environment and disease: association or causation? London: SAGE Publications; 1965.

  8. Peters MD, Godfrey CM, Khalil H, McInerney P, Parker D, Soares CB. Guidance for conducting systematic scoping reviews. Int J Evid Based Healthc. 2015;13(3):141–6.

    Article  PubMed  Google Scholar 

  9. Aartun E, Hartvigsen J, Boyle E, Hestbaek L. No associations between objectively measured physical activity and spinal pain in 11-15-year-old Danes. Eur J Pain. 2016;20(3):447–57.

    Article  CAS  PubMed  Google Scholar 

  10. Auvinen JP, Tammelin TH, Taimela SP, Zitting PJ, Jarvelin MR, Taanila AM, et al. Is insufficient quantity and quality of sleep a risk factor for neck, shoulder and low back pain? A longitudinal study among adolescents. Eur Spine J. 2010;19(4):641–9.

    Article  PubMed  Google Scholar 

  11. Balagué F, Bibbo E, Mélot C, Szpalski M, Gunzburg R, Keller TS. The association between isoinertial trunk muscle performance and low back pain in male adolescents. Eur Spine J. 2010;19(4):624–32.

    Article  PubMed  Google Scholar 

  12. Deere KC, Clinch J, Holliday K, McBeth J, Crawley EM, Sayers A, et al. Obesity is a risk factor for musculoskeletal pain in adolescents: findings from a population-based cohort. Pain. 2012;153(9):1932–8.

    Article  PubMed  Google Scholar 

  13. Feldman DE, Shrier I, Rossignol M, Abenhaim L. Work is a risk factor for adolescent musculoskeletal pain. J Occup Environ Med. 2002;44(10):956–61.

    Article  PubMed  Google Scholar 

  14. Feldman DE, Rossignol M, Shrier I, Abenhaim LS. A risk factor for development of low back pain in adolescents. Spine (Phila Pa 1976). 1999;24(23):2492–6.

    Article  CAS  Google Scholar 

  15. Franz C, Møller NC, Korsholm L, Jespersen E, Hebert JJ, Wedderkopp N. Physical activity is prospectively associated with spinal pain in children (CHAMPS study-DK). Sci Rep. 2017;7(1):11598.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Franz C, Jespersen E, Rexen C, Leboeuf-Yde C, Wedderkopp N. Back injuries in a cohort of schoolchildren aged 6–12: a 2.5-year prospective study. Scand J Med Sci Sports. 2016;26(8):911–8.

    Article  CAS  PubMed  Google Scholar 

  17. Gill DK, Davis MC, Smith AJ, Straker LM. Bidirectional relationships between cigarette use and spinal pain in adolescents accounting for psychosocial functioning. Br J Health Psychol. 2014;19(1):113–31.

    Article  PubMed  Google Scholar 

  18. Hebert JJ, Leboeuf-Yde C, Franz C, Lardon A, Hestbæk L, Manson N, et al. Pubertal development and growth are prospectively associated with spinal pain in young people (CHAMPS study-DK). Eur Spine J. 2019;28:1565-71.

  19. Hestbaek L, Leboeuf-Yde C, Kyvik KO. Are lifestyle-factors in adolescence predictors for adult low back pain? A cross-sectional and prospective study of young twins. BMC Musculoskelet Disord. 2006;7:27.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Hestbaek L, Leboeuf-Yde C, Kyvik KO. Is comorbidity in adolescence a predictor for adult low back pain? A prospective study of a young population. BMC Musculoskelet Disord. 2006;7(1):29.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Hestbaek L, Leboeuf-Yde C, Kyvik KO, Manniche C. The course of low back pain from adolescence to adulthood: eight-year follow-up of 9600 twins. Spine (Phila Pa 1976). 2006;31(4):468–72.

    Article  Google Scholar 

  22. Janssens KA, Rosmalen JG, Ormel J, Verhulst FC, Hunfeld JA, Mancl LA, et al. Pubertal status predicts back pain, overtiredness, and dizziness in American and Dutch adolescents. Pediatrics. 2011;128(3):553–9.

    PubMed  PubMed Central  Google Scholar 

  23. Jones GT, Macfarlane GJ. Predicting persistent low back pain in schoolchildren: a prospective cohort study. Arthritis Rheum. 2009;61(10):1359–66.

    Article  PubMed  Google Scholar 

  24. Jones GT, Watson KD, Silman AJ, Symmons DP, Macfarlane GJ. Predictors of low back pain in British schoolchildren: a population-based prospective cohort study. Pediatrics. 2003;111(4 Pt 1):822–8.

    Article  PubMed  Google Scholar 

  25. Kanchanomai S, Janwantanakul P, Pensri P, Jiamjarasrangsi W. A prospective study of incidence and risk factors for the onset and persistence of low back pain in Thai university students. Asia Pac J Public Health. 2015;27(2):Np106–15.

    Article  PubMed  Google Scholar 

  26. Kroner-Herwig B, Gorbunova A, Maas J. Predicting the occurrence of headache and back pain in young adults by biopsychological characteristics assessed at childhood or adolescence. Adolesc Health Med Ther. 2017;8:31–9.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Mattila VM, Saarni L, Parkkari J, Koivusilta L, Rimpelä A. Predictors of low back pain hospitalization–a prospective follow-up of 57,408 adolescents. Pain. 2008;139(1):209–17.

    Article  PubMed  Google Scholar 

  28. Mikkonen P, Heikkala E, Paananen M, Remes J, Taimela S, Auvinen J, et al. Accumulation of psychosocial and lifestyle factors and risk of low back pain in adolescence: a cohort study. Eur Spine J. 2016;25(2):635–42.

    Article  PubMed  Google Scholar 

  29. Mikkonen PH, Laitinen J, Remes J, Tammelin T, Taimela S, Kaikkonen K, et al. Association between overweight and low back pain: a population-based prospective cohort study of adolescents. Spine (Phila Pa 1976). 2013;38(12):1026–33.

    Article  Google Scholar 

  30. Mikkonen P, Leino-Arjas P, Remes J, Zitting P, Taimela S, Karppinen J. Is smoking a risk factor for low back pain in adolescents? A prospective cohort study. Spine (Phila Pa 1976). 2008;33(5):527–32.

    Article  Google Scholar 

  31. Nissinen M, Heliovaara M, Seitsamo J, Alaranta H, Poussa M. Anthropometric measurements and the incidence of low back pain in a cohort of pubertal children. Spine (Phila Pa 1976). 1994;19(12):1367–70.

    Article  CAS  Google Scholar 

  32. Sano A, Hirano T, Watanabe K, Endo N, Ito T, Tanabe N. Body mass index is associated with low back pain in childhood and adolescence: a birth cohort study with a 6-year follow-up in Niigata City, Japan. Eur Spine J. 2015;24(3):474–81.

    Article  PubMed  Google Scholar 

  33. Sjolie AN. Persistence and change in nonspecific low back pain among adolescents: a 3-year prospective study. Spine (Phila Pa 1976). 2004;29(21):2452–7.

    Article  Google Scholar 

  34. Smith A, Beales D, O'Sullivan P, Bear N, Straker L. Low Back pain with impact at 17 years of age is predicted by Early adolescent risk factors from multiple domains: analysis of the Western Australian pregnancy cohort (Raine) study. J Orthop Sports Phys Ther. 2017;47(10):752–62.

    Article  PubMed  Google Scholar 

  35. Szita J, Boja S, Szilagyi A, Somhegyi A, Varga PP, Lazary A. Risk factors of non-specific spinal pain in childhood. Eur Spine J. 2018;27(5):1119–26.

    Article  PubMed  Google Scholar 

  36. Szpalski M, Gunzburg R, Balague F, Nordin M, Melot C. A 2-year prospective longitudinal study on low back pain in primary school children. Eur Spine J. 2002;11(5):459–64.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Tobias JH, Deere K, Palmer S, Clark EM, Clinch J. Joint hypermobility is a risk factor for musculoskeletal pain during adolescence: findings of a prospective cohort study. Arthritis Rheum. 2013;65(4):1107–15.

    Article  PubMed  Google Scholar 

  38. Aggarwal N, Anand T, Kishore J, Ingle GK. Low back pain and associated risk factors among undergraduate students of a medical college in Delhi. Educ Health (Abingdon). 2013;26(2):103–8.

    Article  Google Scholar 

  39. Andersen L, Wedderkopp N, Leboeuf-Yde C. Association between back pain and physical fitness in adolescents. Spine (Phila Pa 1976). 2006;31(15):1740–4.

    Article  Google Scholar 

  40. Balague F, Nordin M, Skovron ML, Dutoit G, Yee A, Waldburger M. Non-specific low-back pain among schoolchildren: a field survey with analysis of some associated factors. J Spinal Disord. 1994;7(5):374–9.

    CAS  PubMed  Google Scholar 

  41. Bejia I, Abid N, Ben Salem K, Letaief M, Younes M, Touzi M, et al. Low back pain in a cohort of 622 Tunisian schoolchildren and adolescents: an epidemiological study. Eur Spine J. 2005;14(4):331–6.

    Article  PubMed  Google Scholar 

  42. Cakmak A, Yucel B, Ozyalcn SN, Bayraktar B, Ural HI, Duruoz MT, et al. The frequency and associated factors of low back pain among a younger population in Turkey. Spine (Phila Pa 1976). 2004;29(14):1567–72.

    Article  Google Scholar 

  43. Dianat I, Alipour A, Asghari Jafarabadi M. Prevalence and risk factors of low back pain among school age children in Iran. Health Promot Perspect. 2017;7(4):223–9.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Dianat I, Sorkhi N, Pourhossein A, Alipour A, Asghari-Jafarabadi M. Neck, shoulder and low back pain in secondary schoolchildren in relation to schoolbag carriage: should the recommended weight limits be gender-specific? Appl Ergon. 2014;45(3):437–42.

    Article  PubMed  Google Scholar 

  45. Diepenmaat AC, van der Wal MF, de Vet HC, Hirasing RA. Neck/shoulder, low back, and arm pain in relation to computer use, physical activity, stress, and depression among Dutch adolescents. Pediatrics. 2006;117(2):412–6.

    Article  CAS  PubMed  Google Scholar 

  46. Erne C, Elfering A. Low back pain at school: unique risk deriving from unsatisfactory grade in maths and school-type recommendation. Eur Spine J. 2011;20(12):2126–33.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Fernandes JA, Genebra CV, Maciel NM, Fiorelli A, de Conti MH, De Vitta A. Low back pain in schoolchildren: a cross-sectional study in a western city of Sao Paulo state, Brazil. Acta Ortop Bras. 2015;23(5):235–8.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Ganesan S, Acharya AS, Chauhan R, Acharya S. Prevalence and risk factors for low Back pain in 1,355 young adults: a cross-sectional study. Asian Spine J. 2017;11(4):610–7.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Ghandour RM, Overpeck MD, Huang ZJ, Kogan MD, Scheidt PC. Headache, stomachache, backache, and morning fatigue among adolescent girls in the United States: associations with behavioral, sociodemographic, and environmental factors. Arch Pediatr Adolesc Med. 2004;158(8):797–803.

    Article  PubMed  Google Scholar 

  50. Gilkey DP, Keefe TJ, Peel JL, Kassab OM, Kennedy CA. Risk factors associated with back pain: a cross-sectional study of 963 college students. J Manip Physiol Ther. 2010;33(2):88–95.

    Article  Google Scholar 

  51. Graup S, de Araujo Bergmann ML, Bergmann GG. Prevalence of nonspecific lumbar pain and associated factors among adolescents in Uruguaiana, state of Rio Grande do Sul. Rev Bras Ortop. 2014;49(6):661–7.

    Article  PubMed  PubMed Central  Google Scholar 

  52. Gunzburg R, Balague F, Nordin M, Szpalski M, Duyck D, Bull D, et al. Low back pain in a population of school children. Eur Spine J. 1999;8(6):439–43.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Haag TB, Mayer HM, Schneider AS, Rumpf MC, Handel M, Schneider C. Risk assessment of back pain in youth soccer players. Res Sports Med. 2016;24(4):395–406.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Harreby M, Nygaard B, Jessen T, Larsen E, Storr-Paulsen A, Lindahl A, et al. Risk factors for low back pain in a cohort of 1389 Danish school children: an epidemiologic study. Eur Spine J. 1999;8(6):444–50.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Hestbaek L, Korsholm L, Leboeuf-Yde C, Kyvik KO. Does socioeconomic status in adolescence predict low back pain in adulthood? A repeated cross-sectional study of 4,771 Danish adolescents. Eur Spine J. 2008;17(12):1727–34.

    Article  PubMed  PubMed Central  Google Scholar 

  56. Hulsegge G, van Oostrom SH, Picavet HS, Twisk JW, Postma DS, Kerkhof M, et al. Musculoskeletal complaints among 11-year-old children and associated factors: the PIAMA birth cohort study. Am J Epidemiol. 2011;174(8):877–84.

    Article  PubMed  Google Scholar 

  57. Jones GT, Silman AJ, Macfarlane GJ. Parental pain is not associated with pain in the child: a population based study. Ann Rheum Dis. 2004;63(9):1152–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Kaspiris A, Grivas TB, Zafiropoulou C, Vasiliadis E, Tsadira O. Nonspecific low back pain during childhood: a retrospective epidemiological study of risk factors. J Clin Rheumatol. 2010;16(2):55–60.

    Article  PubMed  Google Scholar 

  59. Kovacs FM, Gestoso M, Gil del Real MT, Lopez J, Mufraggi N, Mendez JI. Risk factors for non-specific low back pain in schoolchildren and their parents: a population based study. Pain. 2003;103(3):259–68.

    Article  PubMed  Google Scholar 

  60. Kristensen C, Bø K, Ommundsen Y. Level of physical activity and low back pain in randomly selected 15-year-olds in Oslo, Norway -- an epidemiological study based on survey. Adv Physiother. 2001;3(2):86–91.

    Google Scholar 

  61. Kristjansdottir G, Rhee H. Risk factors of back pain frequency in schoolchildren: a search for explanations to a public health problem. Acta Paediatr. 2002;91(7):849–54.

    Article  CAS  PubMed  Google Scholar 

  62. Leboeuf-Yde C, Wedderkopp N, Andersen LB, Froberg K, Hansen HS. Back pain reporting in children and adolescents: the impact of parents' educational level. J Manip Physiol Ther. 2002;25(4):216–20.

    Article  Google Scholar 

  63. LeResche L, Mancl LA, Drangsholt MT, Saunders K, Von Korff M. Relationship of pain and symptoms to pubertal development in adolescents. Pain. 2005;118(1–2):201–9.

    Article  PubMed  Google Scholar 

  64. Masiero S, Carraro E, Celia A, Sarto D, Ermani M. Prevalence of nonspecific low back pain in schoolchildren aged between 13 and 15 years. Acta Paediatr. 2008;97(2):212–6.

    Article  PubMed  Google Scholar 

  65. Mattila VM, Sahi T, Jormanainen V, Pihlajamaki H. Low back pain and its risk indicators: a survey of 7,040 Finnish male conscripts. Eur Spine J. 2008;17(1):64–9.

    Article  PubMed  Google Scholar 

  66. Minghelli B, Oliveira R, Nunes C. Non-specific low back pain in adolescents from the south of Portugal: prevalence and associated factors. J Orthop Sci. 2014;19(6):883–92.

    Article  PubMed  Google Scholar 

  67. Mohseni-Bandpei MA, Bagheri-Nesami M, Shayesteh-Azar M. Nonspecific low back pain in 5000 Iranian school-age children. J Pediatr Orthop. 2007;27(2):126–9.

    Article  PubMed  Google Scholar 

  68. Ng L, Perich D, Burnett A, Campbell A, O'Sullivan P. Self-reported prevalence, pain intensity and risk factors of low back pain in adolescent rowers. J Sci Med Sport. 2014;17(3):266–70.

    Article  PubMed  Google Scholar 

  69. Noll M, Candotti CT, Rosa BN, Loss JF. Back pain prevalence and associated factors in children and adolescents: an epidemiological population study. Rev Saude Publica. 2016;50:31.

  70. Noll M, de Avelar IS, Lehnen GC, Vieira MF. Back pain prevalence and its associated factors in Brazilian athletes from public high schools: a cross-sectional study. PLoS One. 2016;11(3):e0150542.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  71. Onofrio AC, da Silva MC, Domingues MR, Rombaldi AJ. Acute low back pain in high school adolescents in southern Brazil: prevalence and associated factors. Eur Spine J. 2012;21(7):1234–40.

    Article  PubMed  Google Scholar 

  72. Pasanen K, Rossi M, Parkkari J, Kannus P, Heinonen A, Tokola K, et al. Low Back pain in young basketball and floorball players. Clin J Sport Med. 2016;26(5):376–80.

    Article  PubMed  Google Scholar 

  73. Prista A, Balagué F, Nordin M, Skovron ML. Low back pain in Mozambican adolescents. Eur Spine J. 2004;13(4):341–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Rodriguez-Oviedo P, Ruano-Ravina A, Perez-Rios M, Garcia FB, Gomez-Fernandez D, Fernandez-Alonso A, et al. School children's backpacks, back pain and back pathologies. Arch Dis Child. 2012;97(8):730–2.

    Article  PubMed  Google Scholar 

  75. Scarabottolo CC, Pinto RZ, Oliveira CB, Zanuto EF, Cardoso JR, Christofaro DGD. Back and neck pain prevalence and their association with physical inactivity domains in adolescents. Eur Spine J. 2017;26:2274-80.

  76. Shehab D, Al-Jarallah K, Al-Ghareeb F, Sanaseeri S, Al-Fadhli M, Habeeb S. Is low-back pain prevalent among Kuwaiti children and adolescents? A governorate-based study. Med Princ Pract. 2004;13(3):142–6.

    Article  PubMed  Google Scholar 

  77. Sheir-Neiss GI, Kruse RW, Rahman T, Jacobson LP, Pelli JA. The association of backpack use and back pain in adolescents. Spine (Phila Pa 1976). 2003;28(9):922–30.

    Google Scholar 

  78. Shipp EM, Cooper SP, Del Junco DJ, Delclos GL, Burau KD, Tortolero SR. Severe back pain among farmworker high school students from Starr County, Texas: baseline results. Ann Epidemiol. 2007;17(2):132–41.

    Article  PubMed  Google Scholar 

  79. Silva GR, Pitangui AC, Xavier MK, Correia-Junior MA, De Araujo RC. Prevalence of musculoskeletal pain in adolescents and association with computer and videogame use. J Pediatr. 2016;92(2):188–96.

    Article  Google Scholar 

  80. Silva MR, Badaro AF, Dall'Agnol MM. Low back pain in adolescent and associated factors: a cross sectional study with schoolchildren. Braz J Phys Ther. 2014;18(5):402–9.

    Article  PubMed  PubMed Central  Google Scholar 

  81. Skaggs DL, Early SD, D'Ambra P, Tolo VT, Kay RM. Back pain and backpacks in school children. J Pediatr Orthop. 2006;26(3):358–63.

    Article  PubMed  Google Scholar 

  82. Turk Z, Vauhnik R, Micetic-Turk D. Prevalence of nonspecific low back pain in schoolchildren in North-Eastern Slovenia. Coll Antropol. 2011;35(4):1031–5.

    PubMed  Google Scholar 

  83. van Gent C, Dols JJ, de Rover CM, Hira Sing RA, de Vet HC. The weight of schoolbags and the occurrence of neck, shoulder, and back pain in young adolescents. Spine (Phila Pa 1976). 2003;28(9):916–21.

    Google Scholar 

  84. Viry P, Creveuil C, Marcelli C. Nonspecific back pain in children. A search for associated factors in 14-year-old schoolchildren. Rev Rhum Engl Ed. 1999;66(7–9):381–8.

    CAS  PubMed  Google Scholar 

  85. Watson KD, Papageorgiou AC, Jones GT, Taylor S, Symmons DP, Silman AJ, et al. Low back pain in schoolchildren: the role of mechanical and psychosocial factors. Arch Dis Child. 2003;88(1):12–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  86. Wedderkopp N, Andersen LB, Froberg K, Leboeuf-Yde C. Back pain reporting in young girls appears to be puberty-related. BMC Musculoskelet Disord. 2005;6:52.

    Article  PubMed  PubMed Central  Google Scholar 

  87. Wedderkopp N, Leboeuf-Yde C, Andersen LB, Froberg K, Hansen HS. Back pain reporting pattern in a Danish population-based sample of children and adolescents. Spine (Phila Pa 1976). 2001;26(17):1879–83.

    Article  CAS  Google Scholar 

  88. Wirth B, Humphreys BK. Pain characteristics of adolescent spinal pain. BMC Pediatr. 2015;15:42.

    Article  PubMed  PubMed Central  Google Scholar 

  89. Wirth B, Knecht C, Humphreys K. Spine day 2012: spinal pain in Swiss school children- epidemiology and risk factors. BMC Pediatr. 2013;13:159.

    Article  PubMed  PubMed Central  Google Scholar 

  90. Yao W, Luo C, Ai F, Chen Q. Risk factors for nonspecific low-back pain in Chinese adolescents: a case-control study. Pain Med. 2012;13(5):658–64.

    Article  PubMed  Google Scholar 

  91. Briggs AM, Smith AJ, Straker LM, Bragge P. Thoracic spine pain in the general population: prevalence, incidence and associated factors in children, adolescents and adults. A systematic review. BMC Musculoskelet Disord. 2009;10:77.

    Article  PubMed  PubMed Central  Google Scholar 

  92. Kamper SJ, Yamato TP, Williams CM. The prevalence, risk factors, prognosis and treatment for back pain in children and adolescents: an overview of systematic reviews. Best Pract Res Clin Rheumatol. 2016;30(6):1021–36.

    Article  PubMed  Google Scholar 

  93. Louw QA, Morris LD, Grimmer-Somers K. The prevalence of low back pain in Africa: a systematic review. BMC Musculoskelet Disord. 2007;8:105.

    Article  PubMed  PubMed Central  Google Scholar 

  94. Calvo-Munoz I, Kovacs FM, Roque M, Gago Fernandez I, Seco Calvo J. Risk factors for low Back pain in childhood and adolescence. A systematic review. Clin J Pain. 2017;34(5):468-84.

  95. Lardon A, Leboeuf-Yde C, Le Scanff C, Wedderkopp N. Is puberty a risk factor for back pain in the young? A systematic critical literature review. Chiropr Man Therap. 2014;22(1):27.

    Article  PubMed  PubMed Central  Google Scholar 

  96. Dario AB, Kamper SJ, OʼKeeffe M, Zadro J, Lee H, Wolfenden L, et al. Family history of pain and risk of musculoskeletal pain in children and adolescents: a systematic review and meta-analysis. Pain. 2019;00:1-10.

  97. Jeffries LJ, Milanese SF, Grimmer-Somers KA. Epidemiology of adolescent spinal pain: a systematic overview of the research literature. Spine. 2007;32(23):2630–7.

    Article  PubMed  Google Scholar 

  98. Hartvigsen J, Nielsen J, Kyvik KO, Fejer R, Vach W, Iachine I, et al. Heritability of spinal pain and consequences of spinal pain: a comprehensive genetic epidemiologic analysis using a population-based sample of 15,328 twins ages 20–71 years. Arthritis Care Res. 2009;61(10):1343–51.

    Article  Google Scholar 

  99. Ferreira PH, Beckenkamp P, Maher CG, Hopper JL, Ferreira ML. Nature or nurture in low back pain? Results of a systematic review of studies based on twin samples. Eur J Pain. 2013;17(7):957–71.

    Article  CAS  PubMed  Google Scholar 

  100. Meeuwisse WH, Tyreman H, Hagel B, Emery C. A dynamic model of etiology in sport injury: the recursive nature of risk and causation. Clin J Sport Med. 2007;17(3):215–9.

    Article  PubMed  Google Scholar 

  101. Ardakani EM, Leboeuf-Yde C, Walker BF. Failure to define low back pain as a disease or an episode renders research on causality unsuitable: results of a systematic review. Chiropr Man Therap. 2018;26(1):1.

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

This research was carried out with funding provided by Chiropractic Australia Research Foundation.

Funding

This study was funded by a scholarship from Murdoch University, Western Australia and funding provided by Chiropractic Australia Research Foundation. JH receives salary support from the Canadian Chiropractic Research Foundation and the New Brunswick Health Research Foundation. The funding sources had no involvement in study design, analysis, interpretation, or manuscript preparation.

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Authors and Affiliations

  1. College of Science, Health, Engineering and Education, Murdoch University, 90 South Street, Murdoch, 6150, Western Australia, Australia

    Amber M Beynon, Jeffrey J Hebert, Charlotte Lebouef-Yde & Bruce F Walker

  2. Faculty of Kinesiology, University of New Brunswick, 3 Bailey Drive, Fredericton, New Brunswick, E3B 5A3, Canada

    Jeffrey J Hebert

  3. Institute for Regional Health Research, University of Southern Denmark, Odense, Denmark

    Charlotte Lebouef-Yde

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  1. Amber M Beynon
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  2. Jeffrey J Hebert
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  3. Charlotte Lebouef-Yde
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  4. Bruce F Walker
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Contributions

All authors contributed to the design of the study. AB conducted the search, study selection and data charting. AB analysed and interpreted the data with the assistance of BW, JH and CLY. AB drafted the manuscript and performed revisions with substantial feedback and editing from all authors. All authors read and approved the final manuscript.

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Correspondence to Amber M Beynon.

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Competing interests

BW and JH are both editors and CLY is Senior Editorial Advisor of Chiropractic & Manual Therapies but played no part in the review of this submission and were blinded to the process. JH is an executive member of the Chiropractic Australia Research Foundation.

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Supplementary information

Additional file 1.

Search strategies used for the literature search. The full search strategy for PubMed and Cochrane databases.

Additional file 2.

PROSPECTIVE STUDIES reporting factors that are longitudinally associated with back pain. Table summarising each included prospective study.

Additional file 3.

CROSS-SECTIONAL STUDIES reporting factors that are associated with back pain. Table summarising included cross-sectional study.

Additional file 4.

Clarity of definitions of Back pain: Prospective studies. Table summarising the clarity of the definitions of back pain in included prospective studies.

Additional file 5.

Clarity of definitions of Back pain: Cross-sectional studies. Table summarising the clarity of the definitions of back pain in included cross-sectional studies.

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Beynon, A.M., Hebert, J.J., Lebouef-Yde, C. et al. Potential risk factors and triggers for back pain in children and young adults. A scoping review, part II: unclear or mixed types of back pain. Chiropr Man Therap 27, 61 (2019). https://doi.org/10.1186/s12998-019-0281-8

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Keywords

Chiropractic & Manual Therapies

ISSN: 2045-709X